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Welcome to the Particles NewsLetter Web Site
Issue: Number 26 July 2000
Editor: Janet Sisterson Ph.D., NPTC

Introduction | Facilities | Patients | HCL HomePage

The is the current issue Particles Newsletter ( Number 26 July 2000) in html format.  There is also a PDF version and MS Word available.  See the Particles Newsletter Archives Section for back issues.

Introduction

Costs: At PTCOG XIX, the Steering Committee decided that part of the registration fee for PTCOG meetings would be used to help produce both Particles and the abstracts of the PTCOG meetings. Only part of the costs is covered in this way, so more financial help is needed from the community. PTCOG is always happy to receive financial gifts; all such gifts are deductible as charitable contributions for federal income tax purposes. The appropriate method is to send a check made out to the "Massachusetts General Hospital" and sent to Janet Sisterson at the address given below.

Facility and Patient Statistics: I continue to collect information about all operating or proposed facilities. Please send me your information. My latest published summary of the worldwide detailed patient statistics through 1997 is:

"World wide proton therapy experience in 1997." Author: J. M. Sisterson. CP475, Application of Accelerators in Research and Industry, eds. J. L. Duggan and I. L. Morgan, AIP Press, New York (1999), p959-962. Copies available on request.

Particles on the Internet: The URLs for the Harvard Cyclotron Laboratory, which contain links to PTCOG and Particles are:

Other proton therapy links:

ARTICLES FOR PARTICLES 27

November 30 2000 is the deadline for news for Particles 27, the January 2001 issue. Address all correspondence for the newsletter to:

Janet Sisterson Ph.D.                         Telephone: (617) 724-1942
Northeast Proton Therapy Center        Fax: (617) 724-9532
Massachusetts General Hospital        E-mail: jsisterson@partners.org
30 Fruit Street, Boston MA 02114

Articles for the newsletter should NOT exceed two pages in length.

PTCOG BUSINESS and FUTURE PTCOG MEETINGS

Chair: Michael Goitein Secretary: Janet Sisterson
Department of Radiation Oncology
Massachusetts General Hospital
Boston MA 02114
Northeast Proton Therapy Center
Massachusetts General Hospital
Boston MA 02114

Steering Committee Members

USA Europe Russia Japan South Africa
W. Chu U. Amaldi V. Khoroshkov K. Kawachi D. Jones
M. Goitein H. Blattmann   H. Tsujii  
D. Miller J.-L. Habrand      
J. Sisterson G. Munkel      
James Slater E. Pedroni      
A. Smith A. Wambersie      
H. D. Suit        
L. Verhey        


The times and locations of the next PTCOG meetings are as follows:

PTCOG XXXIII Berlin, Germany September 25 – 27 2000
PTCOG XXXIV Boston, MA, USA April, May or June 2001
PTCOG XXXV Tsukuba, Japan November 2001

The future of PTCOG

Every now and again it seems worthwhile to focus attention on the status of an organization to determine whether it is fulfilling its function(s) well - and whether there are mid-course corrections of a minor or major kind which should be made. We intend to set aside some time at the next PTCOG meeting in Berlin to at least begin such a discussion – we may then continue the discussion at the following meeting in Boston, if it is indicated. These discussions will begin at the steering committee meeting and will continue at the business meeting.

The following questions seem appropriate:

Is PTCOG meeting the interests of:

experienced physicians in the field
experienced physicists in the field
students
those who are contemplating new facilities
current or prospective commercial and quasi-commercial vendors?

Is PTCOG providing adequate:

scientific discussion
educational experience
commercial interchange?

Are the venues for PTCOG meetings appropriate?

currently, roughly, cycling amongst: one meeting in North America, one in Europe, one elsewhere.

Is the frequency of meetings (presently, 2 times a year) appropriate? Proposals have been heard to:

cut back to once a year
compromise at one meeting roughly every 9 months.

Is the economic basis of PTCOG (everyone pays their way, meetings are break-even, no treasurer!) satisfactory?

should there be annual dues?
should we encourage industrial exhibits and raise money through them?

These, and any additional topics which the steering committee members may wish to raise, will be the subject of an extended steering committee meeting at the Berlin PTCOG. We look forward to seeing you there. If you are unable to be in Berlin but would like to contribute your thoughts and ideas, please send them to Janet Sisterson (jsisterson@partners.org).

Michael Goitein, chair
Janet Sisterson, secretary

Summary of the Steering Committee Meeting,
PTCOG XXXII
Tuesday April 18, Uppsala Sweden.

Present: E. Blomquist, W. Chu, M. Goitein, E. Grusell, J. Sisterson, J. Wilson, D. Nichiporov, J. Heese, H. Kluge, H. Tsujii, B. Gottschalk..

1) Future meetings:

Definite Tentative
September 2000: Berlin, Germany
April, May June 2001: Boston, MA, USA

November 2001: Tsukuba, Japan
Fall 2002: NAC, South Africa

There was much discussion about the details of the program for the Berlin PTCOG meeting. It was resolved to hold a "Public Steering Committee" session at this meeting to discuss the future of PTCOG in regards to the timing and focus of the meetings and issues regarding membership and finances. 

PTCOG XXXIII
September 25-27 2000
Hosted by the Hahn-Meitner-Institut Berlin GmbH, Berlin, Germany

The half-yearly PTCOG meetings concern the present and future role of proton radiotherapy. The preliminary program includes:

  • clinical physics of proton beams;
  • proton beams in ocular oncology and macular degeneration;
  • new developments in proton therapy;
  • clinical results of proton beam radiotherapy.

One special feature of this PTCOG meeting will be the combination with the European Cyclotron Progress Meeting ECPM XXXII, which will be held from September 21-23 at the same location. The ECPM meeting is devoted to cyclotrons and their applications and covers reviews and descriptions of existing machines and equipment, novel solutions and unsolved problems. Please check our website http://www.hmi.de/events/ecpm for details and separate registration. Topics of common interest to both communities will be emphasized in both meetings. In particular, we plan a workshop on Sunday, September 24, tentatively entitled "progress on cyclotrons in radiotherapy".

ABOUT THE ORGANISERS: The meeting is organised by the Ion Beam Laboratory ISL of the Hahn-Meitner-Institut Berlin (HMI). The HMI, located in Berlin-Wannsee and formerly dedicated to nuclear research, is now one of Germany’s scientific research centers specialized in the investigation of structures of solid matter, new materials and manufacturing techniques for photovoltaic cells. The work ranges from basic research to practical applications. A research reactor provides neutron beams for the Berlin Neutron Scattering Center (BENSC) and the particle accelerator produces high energy protons up to heavy ions for the Ion Beam Laboratory ISL. The HMI operates in collaboration with the university clinic Benjamin Franklin in Berlin-Steglitz Germany’s only facility for proton beam treatments of ocular melanoma.

Location and transportation: The meeting takes place at the:

Hotel Steglitz International (SI), Albrechtstr. 2, 12165 Berlin, Germany
Phone: +49 (30) 790050 email info@steglitz.bestwestern.de,
Fax: +49 (30) 79005550 URL: www.si-hotel.com

The hotel is located close to:

U-Bahn station of line U9: Rathaus Steglitz
S-Bahn station of line S1: Rathaus Steglitz
stops of various bus lines

  • If you arrive by train at station Zoologischer Garten, U-Bahn U9 takes you there directly.
  • If you arrive by plane at Tegel airport, take bus X9 to station Zoologischer Garten and then U-Bahn U9 to Rathaus Steglitz.
  • If you arrive at Schönefeld airport, take S-Bahn S45 and change at station Schöneberg to S-Bahn S1 with destination Rathaus Steglitz.
  • You can check any kind of train connections directly through the web service http://bahn.hafas.de giving Rathaus Steglitz (S+U), Berlin as destination.

Tentative Time Schedule

24. 9. 2000 13.00 - 18.00  
18.00 - 20.00  
Workshop on "Progress on Cyclotrons in Radiotherapy"
Reception and Registration
25. 9. 2000 8.30
8.30 - 9.00       
9.00 - 12.30    
12.30 - 14.00
14.00 - 17.00
17.30
18.00 - 19.00
19.00 - 21.00
21.00
Registration
Opening Remarks
Clinical Session
Lunch
Eye Session
Bus Transfer to HMI
Visit of Accelerator and Eye Beam Line
Welcome Buffet at HMI
Bus Transfer to Hotel
26. 9. 2000 7.30 - 9.00
9.00 - 12.30
12.30 - 14.00
14.00 - 16.00
16.00 - 18.00
19.30
PTCOG Steering Committee Meeting
Accelerators, Gantry Design, Scanning, Quality Assurance
Lunch
Poster Session and Coffee
Future of PTCOG (see article on Page 3)
Banquet
27. 9. 2000 9.00 -13.00
13.00 - 14.00
Treatment Planning and Clinical Protocols
Closing Remarks

   
For early arrivals: An excursion is planned for the afternoon of September 23, either a visit to Potsdam, or a boat tour through Berlin.

Call for papers: If you plan to submit a contribution to PTCOG XXXIII, please give the title on the registration form. Talks will be a maximum of 15 minutes including time for discussion. If the session is full, speakers will be informed and asked to consider a poster presentation. The maximum size for a poster is 1.0 x 1.8 meters. Presenters are strongly encouraged to send an abstract of their presentation to both the conference organizers (ptcog@hmi.de) and Janet Sisterson (jsisterson@partners.org) before July 31, 2000. The abstracts will be published with the December 2000 issue of Particles. Abstracts should be about one half page in length, including authors and affiliations. Computer projection, double slide projectors and overhead projectors will be available.

Conference Fee: The conference fee is EUR 230 (DEM 460). The fee covers receptions, coffee breaks and 2 lunches (September 25 and 26). The price for the conference dinner is included in the conference fee. For an accompanying person the cost for the conference dinner is EUR 50 (DEM 100). You may combine the payment with that of the conference fee.

Payment

  • Payment with Euro/Master-Card, Visa and American Express
  • Send a cheque payable to Hahn-Meitner-Institut
  • Payment in cash or with travellers cheques at the registration desk
  • Transfer the conference fee to the bank account of HMI: The bank account of HMI is with Berliner Sparkasse. The account number is 105 000 4007. German banks are identified by bank numbers. For the Berliner Sparkasse it is 100 500 00. From abroad also the so-called swift code of the bank BELA DEBE might be useful. In any case, add the keyword PTCOG, and your name and institution, otherwise we are not able to find your payment.

Deadline for Accommodation in the Conference Hotel: Rooms are reserved at the conference hotel Steglitz International for a special rate of DEM 160 per night for a single and DEM 200 for a double room. Please add DEM 22 per person to include breakfast. Please book directly with the hotel using the keyword HMI. The deadline for the hotel registration is July 31, 2000.

You may also inform yourself about other hotels and book through the internet page http://www.btm.de. The locations of the hotels are found in http://www.stadtplandienst.de, which offers map and search facilities. As tourists and business meetings are usually crowd hotels in Berlin until end of September, we strongly suggest early reservations.

Organising Committee:

J. Heese (chairman), H. Kluge (chairman), M. Fitzek, M. Nausner, I. Reng

For further questions please contact the conference secretary:
Mrs. G. Liar de Martin Phone: +49 30 8062 2415
Hahn-Meitner-Institut / ISL Fax: +49 30 8062 2097
Glienicker Str. 100 Email: ptcog@hmi.de
14109 Berlin, Germany URL: http://www.hmi.de/events

 

Announcement of the

7th Workshop on Heavy Charged Particles in Biology and Medicine
and WE - Heraeus-Seminar 246
GSI, Darmstadt Germany
September 28 - 30, 2000

This workshop will be held after the PTCOG meeting in Berlin. Aim of this workshop will be to understand and discuss the complex dependence of RBE on physical and biological parameters, to compare it to the existing cellular and clinical data, and to dicuss the integration of clinical RBE from charged particles (protons to carbon) and neutrons into treatment planning comparing different model calculations as well as using standard values.

The workshop will consist of overviews as invited talks and poster contributions. There will be ample room for discussion.

Information: http://www.gsi.de/conferences/HCPBM7/

Contact:
K.Langbein,Biophysik,GSI,
Planckstr.1, 64291 Darmstadt, Germany
Tel: +49-6159-71-2139,
Fax: +49-6159-71-2106,
Email: K.Langbein@gsi.de

International Conference on Ocular Pathologies
12 – 13 October 2000
Laboratori Nazionali del Sud – INFN
Catania, Italy

Aim of the conference is to give a meeting point for ophthalmologists, radiotherapists and medical physicists about the status and future perspectives of the treatment of ocular pathologies with proton beams.

Particular care will be devoted to the treatment of tumoral pathologies, like uveal and iris melanomas and of macular degeneration. The status of the existing facilities and new projects will be presented. The treatment planning development will be matter of discussions intercomparing the different clinical experience.

The conference will have four different main sessions:

  • ocular pathologies
  • radiotherapy approach
  • treatment planning
  • clinical dosimetry.

Abstracts: should be submitted to Dr. Giacomo Cuttone (Laboratori Nazionali del Sud – INFN, Via S. Sofia 44 – 95123 Catania, Italy) by : - snail mail; fax (+39-095-542300); email: cuttone@lns.infn.it; on-line: http://www.tera.it/ise/catania.html

Oral and poster contributions have to be presented before July 31st 2000 (no more than 100 words, no figures). A book of abstract will be distributed during the workshop. Proceedings of the conference will be published by Physica Medica.

Preliminary program:

Thursday, October 12th: Ophtalmology – Radiotherapy
Friday, October 13th: Overview of facilities – Clinical Dosimetry – Treatment planning

Registration fee: before August 15th 2000: 300.000 ITL: after August 15th 2000: 400.000 ITL

Modality of payment: should be directed to Istituto Scientifico Europeo by:

Credit card (VISA, Mastercard/Eurocard, American Express): please, note name of cardholder, expiration date and n° of card!!
International Bank Draft (Banca Popolare di Intra, filiale di Novara – CAB:10100 – ABI:05548 – c/c:55600/0)

Hotel Reservation:

Hotel Baia Verde (at the sea) single (195.000 ITL/night) double (260.000 ITL/night)
Hotel Jolly (center of the city) single (160.000 ITL/night) double (195.000 ITL/night)

Scientific Committee:

U. Amaldi – TERA Foundation, Novara, I E. Balestrazzi – Clinica Oculistica, Aquila,
P. Chauvel – Centre A. Lacassagne, Nizza, F L. Conte – Ospedale di Circolo, Varese, I
B. Damato – Royal Univ. Hospital, Liverpool, UK E. Egger – PSI, Villigen, CH
S. Lo Nigro – Università di Catania, I A. Reibaldi – Clinica Oculistica, Catania, I
R. Santoni – Università di Firenze, I D. Vinciguerra – INFN-LNS, Catania, I
M. Zingirian – Clinica Oculistica, Genova, I L. Zografos – Hopital "J. Gonin", Lausanne, CH
A. Kacpereck – Clatterbridge Center for Onc., Bebington, UK

Organizing Committee:

R. Cirio – INFN, Torino – ISE, Arona, I A. Crespi – Ospedale S. Gerardo, Monza, I
G. Cuttone – INFN-LNS, Catania, I A. Hegedus – ISE, Arona, I
G. Nicoletti – Clinica Oculistica, Catania, I G. Privitera – Policlinico, Univ. di Catania, I
L. Raffaele – Policlinico, Univ. di Catania, I G. Ruggieri – INF-LNS, Catania, I
M.G. Sabini – INFN-LNS, Catania, I

For further information:

Agnes Hegedus (Istituto Scientifico Europeo – ISE)
Piazza S. Carlo, 1 – 28041 Arona (NO), Italy
Tel: +39-0322-249700 / Fax: +39-0322-240800
Email: ise@tera.it http://www.tera.it/ise/catania.html

 

PTCOG Information/News/Reports:

The following reports and articles were received by July 2000.

NOTICE: Recently published book: Proton therapy and Radiosurgery. H. Breuer and B. J. Smit

The principle of calculation of the dose-volume curves in Chapter 1 is controversial and should serve to stimulate discussion. At this stage, it is not recommended that the graphs and tables (page 153-163, and references to this section, as well as appendix P3.1 and P3.2 and drawing (a) on page 280) are used for patient management, rather that they should be checked, as suggested in the book, against all existing dose-volume models. B. J. Smit, Dept. of Radiotherapy, Tygerberg Hospital, University of Stellenbosch, Private Bag, Tygerberg 7505, South Africa

The Northeast Proton Therapy Center, Boston, USA: A Status Report

The Northeast Proton Therapy Center (NPTC) is a state-of-the-art proton beam therapy facility under construction at Massachusetts General Hospital in Boston, USA. The therapy equipment (a cyclotron, two gantries, and a fixed horizontal beam) is being built by Ion Beam Applications (IBA) of Belgium under a contract with the MGH which is jointly and roughly equally funded by the MGH and the National Cancer Institute. The contract was let in April, 1994 with a date for the first patient treatment originally envisioned for September, 1998.

The NPTC building is completed and functions well. The great majority of the equipment is on site and has been installed for some time (the cyclotron put out its first beam in June, 1997 and has generally worked well since then). The missing element is the therapy control system (TCS) – a sophisticated computer control system which was mandated by the hospital’s specifications for automated and very efficient operation. This, in turn, was at least partly motivated by the need to transfer the existing and flourishing clinical program at the Harvard Cyclotron Laboratory as soon as the NPTC became operational.

IBA’s first approach to the design and coding of the TCS ran into difficulties and the development had to be out-sourced to a company specializing in control system software development. This introduced a substantial delay into the project. However, the news is now very positive. The design, coding and unit testing of the software is substantially completed, as is the software integration phase (a complex matter of cumulatively assembling software modules and testing the software/hardware interfaces). It is anticipated that before the end of August it should be possible to begin the series of extensive tests of the entire system (software plus hardware combined) which goes under the name of "Verification and Validation." One aspect of the Validation tests is to confirm that treatments can be accurately delivered using the new version (version 1) of the TCS. (Beam experiments have been possible for a long time under the original version 0.) The other critical aspect of the equipment which, we anticipate, will be confirmed in the Validation testing is the day-to-day operational reliability of the entire system.

Once Validation tests are complete, the test results will be submitted to the FDA for per-market clearance – the so-called 510(k) process. Shortly thereafter, acceptance tests will be performed, followed by a period of clinical commissioning, leading up to a first patient treatment on the first gantry. We anticipate that the machine should be accepted by the end of this year, and that the first patient treatment should take place by the end of the first quarter of 2001. The clinical program at HCL will then be transferred to the NPTC over the next several months. Michael Goitein, Northeast Proton Therapy Center, Massachusetts General Hospital, 30 Fruit Street, Boston, MA 02114.

News from ITEP, Moscow, Russia:

The Medical-Physical Department of the Institute of Theoretical and Experimental Physics in Moscow, Russia has opened its webpage where all necessary information about the Department, its staff, collection of papers and some current publications will be included by wishes of the authors from this Department or its co-operators. Works included there in Publication List can be requested from authors, to receive it in English version, if necessary. This information can be found electronically at the following internet address: http://www.protontherapy.itep.ru. E-mail addresses of contacts are Michael.Lomanov@itep.ru and Igor.Tarasov@itep.ru.

Michael Lomanov, Institute of Theoretical and Experimental Physics, B. Cheremushkinskaya 25, Moscow 117259, Russia.

<AntiGANTRY> (<AG>) - a new system of engineering and technology of rotational-scanning proton/heavy ion-therapy without GANTRY.

Hadron-therapy still remains extremely expensive, and the lion's part of necessary expensives is not on accelerator, but on GANTRYs and other medical part. So, it is necessary to search the way for lower investment costs on a medi-co-technical part. With this purpose we tender a new System <AG> of an irradiation of an upright posed patient by a horizontal beam of protons or multicharge ions.

We fulfilling a fixation of patient in a thin-wall Shell, which is looking like cylinder, cut up on two halves along (Fig.1). A hermetic bag 2 filled on by small-sized plastic pellets is put in a horizontally posed inferior half 1 of the Shell. The patient 3 is put down on a bag. Than pump 4 suck out an air from the bag and the bag becomes solid. Further we cover the patient over by second bag 5, and the second half 7 of Shell, and after we connect both halves of Shell in a unit. Such hardened bags are stored in a "library" and used for fixing given patient daily. The well-known American firm MED-TEC inc. guarantees a safety of the relief of the surface of bags within 6-7 weeks

 

The Shell is established on the Mobile Stand (Fig.2). The upper and lower backs 8 of the Shell, are put in girder 9. Turning the girder about horizontal axis 10, we turn up the Shell in vertical position. The girder is moved up- and downward along a vertical mount 11 of the Stand. During a rotational-scanning irradiation, the Shell with patient is rotated around of a vertical axis and moved in horizontal and vertical directions under a fixed or scanning horizontal narrow beam of particles 12. The design of the Stand allows to place the Shell with patient not only vertically, but also in horizontal or in any intermediate position.   In these cases is carry out an irradiation with a method of linear scanning.

The patients are prepared for an irradiation (including fixation, centration, serial horizontal CT-tomography) simultaneously and separately in six Preparatory procedural rooms, placed outside of a zone of irradiation. The computer aided transport system automatically delivers the next patient from Preparatory procedural room to Radiative one and back together with his Mobile Stand, without infringement of quality of fixation and centration (for example, on a guide 13 or magnetic pillow). Besides, through Radiative room, the Stands with patients are transported always two by two, in one direction, by the method which one we have termed as the pendulum conveyer.

Such organization of preparation and irradiation of the patients allows to take the most of throughput of the accelerator (up to 1000-1200 patients/ year) and carry out the most conformal method - a rotational-scanning or linear-scanning irradiation of tumours of any forms, sizes and localizations. <AG> can work with any medical accelerator of protons/ions needlessly either constructive alteration or adaptation. The area of 300 sq.m. is necessary for accommodation <AG>-system (without rooms for the accelerator and the stuff). The cost price of a serial copy of <AG>-system will make about 1 million bucks (including cost of horizontal computer Tomographs of an original construction in any of procedural rooms). That is in tens time cheaper than systems applying GANTRY to protons and in hundreds time cheaper than similar systems to ions of Carbon (?12).

Throughput of the <AG>-system is up to 1000-1200 patients per one year, and it carry out a rotational-scanning or linear-scanning irradiation of tumours of any forms, sizes and localizations. <AG> can work with any medical accelerator of protons/ions needlessly either constructive alteration or adaptaton. The area of 300 sq.m. is necessary for accommodation <AG>- system (without rooms for the accelerator and the stuff). The cost price of a serial copy of system will make about 1 million bucks, including cost of horizontal computer tomographs of an original construction in any of Preparatory procedural rooms. B. Astrakhan, Russian Cancer Research Center RAMS, 24, Kashirsckoye schosse, 115478 Moscow, Russia (astrakob@online.ru.).

 Robert Rathbun Wilson 1914-2000.

Robert Rathbun Wilson (center) at Harvard University in the mid 1940s. The photograph is from the files of the Harvard Cyclotron Laboratory, P. W. Bridgeman is on the right, but why, when, where this photograph was taken is not recorded.

Robert Rathbun Wilson died on January 16 2000 at his home in Ithaca, New York at the age of 85. He has been one of the most important figures in the history of the development of particle accelerators. He is probably best known for leading the team that designed and built the highly successful Fermi National Accelerator Laboratory – Fermilab. As well as accomplishing this enormous technical feat, Wilson conceived and created the attractive and unusual environment in which Fermilab is located. Robert Wilson was also an accomplished artist and some of his sculptures are displayed on the grounds of Fermilab, as well as at Harvard University and the Northeast Proton Therapy Center, Massachusetts General Hospital.

While Robert Wilson accomplished many bigger and better things in his productive life, to the proton radiation therapy community, he is probably best known for the seminal paper (R. R. Wilson (1946). Radiological use of fast protons. Radiology 47, 487-91) which was written while he was a member of the Physics Department at Harvard University. This paper was intended to "acquaint medical and biological workers with some of the physical properties and possibilities of such rays. To be as simple as possible, let us consider only high-energy protons: later we can generalize to other particles."

The paper summarizes the properties of proton beams that could be used to advantage in medical applications and predicts that accelerators under construction at that time should easily be able to produce sufficient current for medical applications. Not only does this paper describe the properties of proton beams, but it also suggests the use of "a rotating wheel of variable thickness, corresponding to the tumor thickness between the source and the patient" to cover the whole volume with the "very high ionization density which obtains over the last few millimeters" when treating large tumors. It also suggests that "the exposure can be monitored precisely simply by placing a shallow ionization chamber between source and patient. Absolute determinations of the dosage can be determined by measuring ionization currents in gases of the elements of tissue or in a gas which mocks up the molecular formula of tissue."

Robert Wilson was invited to address the Second International Symposium on Hadrontherapy held at CERN in 1996 – fifty years since he wrote that profound paper. In his talk (Advances in Hadrontherapy, Excerpta Medica, Int. Cong. Series 1144. Eds: U. Amaldi and B. Larsson, Elsevier, pp ix-xiii, 1997), he described how he came to write the paper describing the properties of proton beams when his immediate mission then had been to just find the penetration of 150 MeV protons in various materials for radiation protection purposes. In discussing what led him to investigate the penetration of protons in tissue-like material, he states " I found the range in brass was going to be several inches while a few inches of lead would fix everything. That was the solution and I should have then gone on to other problems in designing the machine, but I did not stop. Why? There was no reason I should go on to anything beyond that, since I had done the job as far as the engineering design of that machine. Fifty years later I do not know why I did not stop. I suppose the first reason was just simple curiosity to find out a little bit more………………So I went on, and instead of just talking about the penetration of particles, I jumped into the almost obvious thing that I could see next: because one could hurt people with protons, one could probably help them too. So I tried to work out every detail I could from the scattering to the Bragg curve………………"

Such lively curiosity, imagination, scientific competence and humanity will be sorely missed.

Janet Sisterson

 TREATMENT PLANNING SYSTEMS FOR PROTON THERAPY
July 2000

The following Table was presented in October 1999 by Skip Rosenthal, MGH at the Workshop on Treatment Planning Systems, PTCOG XXXI. Information was provided by: S. Rosenthal, A. Mazal, M. Collier, T. Lomax, S. Nill, and D. Miller. This Table is a new feature of Particles, and will be updated each issue. Please send corrections/additions to Janet Sisterson.

Year Created By System Name Status
1979-93 LBL LBL system Not Available
1980 MGH Rx Distributor MGH
1980 MGH EYEPLAN Distributor MGH – EYES only
1990-96 MGH/Seimens V-Treat(AXIOM) Not Available
198?,1991 PSI PSI system/Pion Distributor PSI
1995 DKFZ/Royal Marsden Voxelplan/Proxelplan Adapted by GSI, NAC, DKFZ
1996 Radionics/MGH/HCL P-Knife Not Available
1997 LLUMC/PerMedics OptiRad 3D Commercial Pending FDA
1998 Tsukuba Hitachi system In-house system
1998 DKFZ OCTOPUS Under development – EYES only
1994 Orsay/Curie ISIS Distribution ?
1998 CMS/MGH FOCUS Commercial Release 1999
1998 DKFZ KonRad Plus Protons Research Only
199? Uppsala/KVI Helax (+ protons) Distribution ?
  RenderPlan   ?
  Adac   ?
  Michigan   ?
  Varian   ?

 

Proposed NEW FACILITIES for PROTON & ION BEAM THERAPY - July 2000

INSTITUTION PLACE TYPE

1ST RX?

COMMENTS
INFN-LNS, Catania Italy

p

2000

70 MeV; 1 room, fixed horiz. beam
NPTC (Harvard) MA USA

p

2001

at MGH; 230 MeV cyclotron; 2 gantries + 2 horiz
Hyogo Japan

p, ion

2001

2 gantries; 2 horiz; 1 vert; 1 45 deg; nearing completion
NAC, Faure South Africa

p

2001

new treatment room with beam line 30o off vertical.
Tsukuba Japan

p

2001

270 MeV;2 gantries;2 fixed; construction complete
Wakasa Bay Japan  

2002

multipurpose accelerator; building completed mid 1998
Bratislava Slovakia

p, ion

2003

72 MeV cyclotron; p; ions; +BNCT, isot prod.
IMP, Lanzhou PR China

C-Ar ion

2003

C-ion from 100MeV/u at HIRFL expand to 900 MeV/u at CSR;clin. treat;biol. research;no gantry;shifted patients
CGMH, Northern Taiwan Taiwan

p

2001?

250MeV synchrotron/230MeV cyclotron;3 gantry,1 fixed
Shizuoka Cancer Center Japan  

2002?

synchrotron 230? MeV; 2 gantries; 1 horiz; funded.
Erlangen Germany

p

2002?

4 treatment rooms, some with gantries.
CNAO, Milan & Pavia Italy

p, ion

2004?

synchrotron; 2 gantry;1 fixed beam rooms;1 exp. room
Heidelberg Germany

p, ion

2005?

 
AUSTRON Austria

p, ion

?

2p gantry;1 ion gantry;1 fixed p;1 fixed ion;1 exp room
Beijing China

p

?

250 MeV synchrotron.
Central Italy Italy

p

?

cyclotron; 1 gantry; 1 fixed
Clatterbridge England

p

?

upgrade using booster linear accelerator to 200 MeV?
TOP project ISS Rome Italy

p

?

70 MeV linac; expand to 200 MeV?
3 projects in Moscow Russia

p

?

including 320 MeV; compact, probably no gantry
Krakow Poland

p

?

60 MeV proton beam.
Proton Development N.A. Inc. IL USA

p

?

300 MeV protons; therapy & lithography
PTCA, IBA USA

p

?

Several systems throughout the USA

 

WORLD WIDE CHARGED PARTICLE PATIENT TOTALS

July 2000

WHO WHERE WHAT

DATE

DATE

RECENT

DATE

     

FIRST

LAST

PATIENT

OF

     

RX

RX

TOTAL

TOTAL

Berkeley 184 CA. USA p

1954

— 1957

30

 
Berkeley CA. USA He

1957

— 1992

2054

June-91

Uppsala Sweden p

1957

— 1976

73

 
Harvard MA. USA p

1961

 

8558

July-00

Dubna Russia p

1967

— 1974

84

 
Moscow Russia p

1969

 

3268

June-00

Los Alamos NM. USA p -

1974

— 1982

230

 
St. Petersburg Russia p

1975

 

1029

Jun-98

Berkeley CA. USA heavy ion

1975

— 1992

433

June-91

Chiba Japan p

1979

 

133

Apr-00

TRIUMF Canada p -

1979

— 1994

367

Dec-93

PSI (SIN) Switzerland p -

1980

— 1993

503

 
PMRC, Tsukuba Japan p

1983

 

629

Jul-99

PSI (72 MeV) Switzerland p

1984

 

3014

Dec-99

Dubna Russia p

1987

 

58

June-00

Uppsala Sweden p

1989

 

236

June-00

Clatterbridge England p

1989

 

999

June-00

Loma Linda CA. USA p

1990

 

5262

July-00

Louvain-la-Neuve Belgium p

1991

– 1993

21

 
Nice France p

1991

 

1590

June-00

Orsay France p

1991

 

1527

Dec-99

N.A.C. South Africa p

1993

 

367

June-00

MPRI IN USA p

1993

 

34

Dec-99

UCSF - CNL CA USA p

1994

 

284

June-00

HIMAC, Chiba Japan heavy ion

1994

 

745

Dec-99

TRIUMF Canada p

1995

 

57

June-00

PSI (200 MeV) Switzerland p

1996

 

41

Dec-99

G.S.I Darmstadt Germany heavy ion

1997

 

72

June-00

Berlin Germany p

1998

 

105

Dec-99

NCC, Kashiwa Japan p

1998

 

35

June-00

         

1100

pions
         

3304

ions
         

27434

protons
        TOTAL

31838

all particles

Disclaimer: The information and reference materials contained herein is intended solely for the information of the reader. It should not be used for treatment purposes, but rather for discussion with the patient's own physician.© Copyright


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