Christopher J. Owen
Research Associate
Intro  |  Research  |  Technology Systems

• Director, Neurosurgery Information Systems
• Director, Neurosurgery Surgical Research Laboratory
• Research Associate in Surgery (Neurosurgery),
  Harvard Medical School

My primary responsibilities, as an Associate in Surgery (Neurosurgery) [Harvard Appointment], are in the management of a research laboratory at MGH where I direct the Neurosurgery Surgical Research Laboratory.  I work for Dr Robert L. Martuza, Chief, MGH Neurosurgical Service (see Research@Neurosurgery) where I am also the Director, MGH Neurosurgery Information Systems.

In this capacity, I am an active member of several of standing MGH committees:

• MGH Executive Committee on Research, Subcommittee on Research Facilities (SRF)
• MGH Subcommittee on Research Animal Care (SRAC) 
• Institutional Animal Care and Use Committee (IACUC) - Protocol Review Group (PRG)
• MGH Unit Safety Officer Advisory Committee
• MGH Web Strategy Committee - Internet, and Intranet Web Committee
• WebMaster (WebServant & PageServant) for the MGH Neurosurgical Computer System

Summary - Research Activities - Director, Neurosurgery Surgical Research Laboratories

In the Neurosurgery Surgical Research Laboratories, there are multiple ongoing basic and preclinical research projects involving studies of functional neurosurgery, neuroregeneration & degeneration, cerebral vasospasm, stroke, neuroimaging, neurotransplantation and gene therapy. These studies range from basic bench-top assays of components involved in metabolic and/or pathophysiological pathways, to surgical models of disease pathways and treatments, to innovative use of new technologies, to imaging studies (PET, fCT, fMRI) of physiological changes involved in these disease processes.

In addition to the variety of research support requirements, I also provide some departmental wide low level support on PC and MAC computer issues. This also includes some technical support on high end Unix workstations used for medical image analysis in support of OR surgical case planning.

Summary - Technology Activities - Director, Neurosurgery Information Systems
Neurosurgical Service (Systems Administrator / Editor / Webmaster)

I am responsible for the development of web systems, html and graphics, that are used in support of the MGH Neurosurgical Service (some of which are listed below). This includes responsibility for both software and hardware issues, maintenance of a series of servers (web & database systems), as well as informational content development.

In addition to the variety of research support requirements, I also provide some departmental wide low level support on PC and MAC computer issues. This also includes some technical support on high end UNIX workstations used for medical image analysis in support of OR surgical case planning.

Research Activities - Research Interests - Research @ Neurosurgery

DR Zervas's Lab - PET Imaging of CBF, CBV, O2M, OEF and GluMetab Research @ Neurosurgery DR N.T. Zervas, Research Info Neurosurgery Surgical Research Lab Neurosurgery Research Labs Images courtesy of Anna-Liisa Brownell, PhD in collaboration on a study of CNS tissue metabolism (rGMR, rCMRO2, rOEF, rCBF, rCBV) during cerebral vasospasm. (For more info.) Research PET Imaging Functional CT Studies Images courtesy of CIPR (Center for Imaging and Pharmaceutical Research) as part of a collaboration with the CNS project group. The images are the work of George Hunter, MD and Leena Hamberg, PhD as part of a study on peripheral tissue perfusion (CBV, TTT, CBFi) during cerebral vasospasm. (For more info.) Center for Imaging and Pharmaceutical Research (CIPR)

DR Zervas's & DR Peterson's Labs - Studies in laser-induced pulsed-fluid wave treatment of vasospastic cerebral arteries. MGH Laser Center DR Peterson's Labs - Studies in Protein Kinase C (PKC). DR J.W. Peterson Laboratory For Cerebrovascular Biophysics Neurophysiology Research Lab -  "Focal Cerebral Ischemia and Neuroprotective Agents." DR C.S. Ogilvy and DR K. Maynard -  Images courtesy of CIPR (Center for Imaging and  Pharmaceutical Research) as part of a collaboration with the CNS project group. Fig 1-3: fCT CBFi maps pre/post focal occlusion. Fig 4-5: fCT delay maps post occlusion.

Technology Activities - Neurosurgical Service (Systems Administrator / Editor / Webmaster)

Neurosurgery at MGH - http://neurosurgery.mgh.harvard.edu
Brain Tumor Center at MGH - http://brain.mgh.harvard.edu
Research Neurosurgery at MGH - http://research.neurosurgery.mgh.harvard.edu
Guest Information Systems - http://gis.mgh.harvard.edu
e-Webs Systems - http://neurosurgery.massgeneral.org

Systems & IPAddresses

Brain (Server) Research (Server) Elliott (Server) Data (Server)

VSP (Server) Zerebus (Server) WWW (Server) WWW2 (Server)

or see

Technology Activities - Patient-to-Patient Services
(Systems Administrator / Webmaster)

Acoustic Neuroma Association - http://ANAusa.org
Brain Aneurysm Foundation - http://BAFusa.org
Facial Neuralgia Association - http://FacialNeuralgia.org
Harvard Cyclotron Laboratory - http://neurosurgery.mgh.harvard.edu/HCL/
Hydrocephalus Association - http://HydroAssoc.org
Hydrocephalus Foundation - http://hydrocephalus.org
Neurofibromatosis Resources - http://neurosurgery.mgh.harvard.edu/NFR/
Pain Center at MGH - http://pain.mgh.harvard.edu
Safety at MGH - http://safety.mgh.harvard.edu
Seattle Acoustic Neuroma Support Group - http://AcousticNeuromaSeattle.org
The Healing Exchange - T.H.E. Brain Trust - http://www.BrainTrust.org
Vision Share, Inc - http://VisionShare.net

Technology Activities - Patient-to-Patient Services
(Systems Administrator / Webmaster)

I have current experience with a variety of operating systems: PC (DOS, Windows 3.x, Win95/98/ME, NT3.51 NT4, NT5, Win2k Professional and Server), some working knowledge of MAC Os's, and some UNIX (HPUX). and some Linux.

I have experience with a variety of software packages including: MS Office (95-2000), Adobe Photoshop, Paradox & FileMaker Databases, a mix of spreadsheet & word processors, scanning & slide making packages, specialty netwoking packages, and CDR & PC hardware systems.

I have demonstrated experience providing services for the Neurosurgery systems and for Hosted systems that includes:

Personal - SomeGraphics (Most all of the graphics on our servers)

If you see a Snake, kill the Snake. Don't form Snake review committees. Don't form Snake discussion groups. Kill the Snake.

Don't kill dead Snakes. Leave them alone, they are dead. Learn from them but move on. Don't get stuck killing dead Snakes.

Observe & Beware. Many good opportunities start as Snakes. Coordinate the discussion to identify which items are Snakes and which are real opportunities.

Journals

Hamberg L.M., et. al.     [See Related Articles]

Functional CT Perfusion Imaging Predicts the Extent of Cerebral Infarction From a 3 Hour MCA Occlusion in a Primate Stroke Model.
Submitted February 2001

Macfarlane R, et al.    [See Related Articles]

Treatment of vasospasm with a 480-nm pulsed-dye laser.
J Neurosurg. 1991 Oct;75(4):613-22.
PMID: 1885979; UI: 91359064.

Teramura A, et al.    [See Related Articles]

Application of the 1-microsecond pulsed-dye laser to the treatment of experimental cerebral vasospasm.
J Neurosurg. 1991 Aug;75(2):271-6.
PMID: 2072166; UI: 91303228.

Peterson JW, et al.    [See Related Articles]

Evidence of the role of hemolysis in experimental cerebral vasospasm.
J Neurosurg. 1990 May;72(5):775-81.
PMID: 2324801; UI: 90218221

Abstracts

B.G. Jenkins*, Y.I. Chen, R. Sanchez Pernaute, C. Owen, A.W. Flaherty; O. Isacson; A.L. Brownell. Mapping Dopaminergic Function in Normal and MPTP Treated Monkeys with Pharmacologic MRI and PET. Society for Neuroscience 31st Annual Meeting, San Diego, CA, November 2001. (abstract and presentation)

Que A, Owen MH, Owen CJ, Holmes, LB.   Relationship between axial defects and abnormal limb in Dh animals.  [Abstract] Northeast Regional Meeting of the Society for Developmental Biology Marine Biological Laboratory, Woods Hole, Massachusetts March 24-26, 2000

Hunter GJ, Hamberg LH, Morris PP, Maynard KI, Lo EH, Owen C, DeBros FM, Choi IS, Tatter SB, Gonzales RG, Wolf GL, Ogilvy CS.   Demonstrati on of the cerebrovascular physiology of acute stroke using high resolution first pass slip-ring CT.   [Abstract] American Society of Neuroradiology, 33rd Annual Meeting, 1995:38.

Steardo, L., Owen, C.J., Hunnicutt, E.J., and Nathanson, J.A. Atriopeptin Receptors in Blood-CSF Barriers. [Abstract]  Soc. for Neurosci. Abstr. vol 12, p1259, 1986.

Nathanson, JA, Hunnicutt, E. and Owen, C.   Atriopeptins in the Eye: Receptors, Second Messengers and Effects on Intraocular Pressure. [Abstract]    Association for Research in Vision and Ophthalmology (ARVO Abstracts) No 49, p273, 1986

Poster Presentation:

High Resolution PET, fMRI, and sMRI in Neuroimaging of the Primate CNS. MIT, Cambridge, MA, September, 2001.

Complementary PET Studies of Striatal Dopaminergic System and Cerebral Metabolism. Society for Neuroscience 30th Annual Meeting, November, 2000.

Relationship between axial defects and abnormal limb in DH animals. Northeast Regional Meeting of the Society for Developmental Biology Marine Biological Laboratory, Woods Hole, Massachusetts March 24-26, 2000

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