Fred Harvey Hochberg, MD

See http://brain.mgh.harvard.edu
or
http://www.massgeneral.org/cancer/cancer_specialist_hochberg.htm

Title Attending Neuro-Oncologist
Office Phone 617-724-8770; 617-726-8657
Fax 617-248-9665; 617-724-8769
Internet Address fhochberg@partners.org
Office Address Massachusetts General Hospital Cancer Center
Stephen E. & Catherine Pappas Center for Neuro-Oncology
Yawkey Center, 9th Floor, Ste 9E
55 Fruit Street
Boston, Massachusetts 02114

Education MD, Columbia College, Case Western Reserve
Postdoctoral Training Cleveland Metropolitan General Hospital
Board Certifications Neurology
Clinical Interests Neuro-Oncology
Publications

Over 160 publications, 80 abstracts

CURRICULUM VITAE

Education:

1963 A.B. Columbia College

1967 M.D. Case-Western Reserve Medical School

Postdoctoral Training:

Internship and Residencies:

1967-1968 Intern, Medical Service, Duke University Medical Center

1968-1970 Resident, Neurology, Cleveland Metropolitan General Hospital

1970-1972 Acting Chief, Neurotrophic Disease Section, Center for Disease Control, Atlanta, Georgia

1972-1975 Clinical and Research Fellow in Neuropathology, Massachusetts General Hospital

1972-1975 Research Fellow in Immunology, Robert, Brigham Hospital (Dr. Schur)

Licensure and Certification:

1976 Massachusetts License Registration

1976 American Board of Psychiatry and Neurology

Academic Appointments:

1975-1978 Instructor in Neurology at Massachusetts General Hospital, Harvard Medical School

1978-1984 Assistant Professor of Neurology, Harvard Medical School

1984-present Associate Professor of Neurology, Harvard Medical School

Hospital Appointments:

1975-1976 Clinical Assistant in Neurology, Massachusetts General Hospital, Boston, MA

1977-1980 Clinical Associate in Neurology, Massachusetts General Hospital, Boston, MA

1981-1982 Assistant in Neurology, Massachusetts General Hospital, Massachusetts General Hospital, Boston, MA

1986-1988 Associate Neurologist, Massachusetts General Hospital, Boston, MA

1989- Neurologist, Massachusetts General Hospital, Boston, MA

Other Professional Positions and Major Visiting Appointments:

1975-1988 Visiting Neurologist, CHUV (University of Lausanne), Department of Neurology (Dr. Regli) and Neuropathology (Dr. Rabinowicz)

1979-present University of Sao Paulo, State University of (visiting) New York, (Syracuse), University of Maryland, Tokyo University, Duke University, Moffatt Cancer Center (Tampa), New York University Medical Center, Brain Tumor Center (Kansas City), Examiner American Board of Neurologic Surgeons, Duke University Medical Center

Editorial Responsibilities:

Editorial Board, CANCER INVESTIGATION

NEUROLOGY CHRONICLE

Memberships, Offices, and Committee Assignments in Professional Societies:

American Academy of Neurology

American Neurologic Association

The New England Cancer Society

Massachusetts Neurologic Society

International Arts Medicine Association

Brain Tumor Collaborative Group

Ad Hoc Member Organ System Advisory Committee (Brain), CTEP, NIH,

Advisory panel: The Association for Brain Tumor Research, Chicago, Ill.

Food and Drug Administration-Orphan Drug Program

Major Research Interests:

1. Neuro-oncology (Primary tumors of the nervous system)
   1. Epidemiology (Glioblastoma, Lymphoma)
   2. Experimental Chemotherapy of Brain Tumors
   3. Viral-Tumor Relationships
   4. Cancer Pain
2. Neurology Disorders of Occupations
   1. Dystonic Disorders-therapy with Botulinum Toxin
   2. Natural History, therapy, risk factors

Teaching Experience:

Courses: (Postgraduate Harvard)

1. Neurology

2. Neurosurgery

3. Cancer Medicine

4. Neuropathology-Harvard Medical School

5. Neuro-oncology

Visiting Lectureships (1987-present):

International Brain Tumor Symposium (Nikko, Japan; Hakone, Japan; Garda, Italy; Zermatt, Switzerland), Peter B. Brigham Hospital, University of Maine, Lynn Hospital, New England Society of Radiation Therapies, Duke University (Honorary Lectureship), Dana Farber Cancer Center, Emerson Hospital (Honorary Lectureship), St. Lukes Hospital (Milwaukee) (Honorary Lectureship)

Principal Clinical and Hospital Service Responsibilities:

1985- Oncology Research/Education Unit,

Brain Tumor and Cancer Pain Units,

Cox Center Committee,

Massachusetts General Hospital

Return to the MGH Neuro-oncology Homepage

PUBLICATIONS

A. Shealy CN, Taslitz N, Hochberg FH. Physiological Standardization of Analgesics and Anesthetics. Lancet: 88:124-128, 1968.

1. Hochberg F, Nelson N: Human Mercury Exposure. A Symposium. Center for Disease Control, 1971.

2. Hochberg F: Organic Mercury Related Neurologic Disease in Mercury in the Western Environment. Oregon State University, Portland, 1971.

3. Hattwick MAW, Hochberg F, and Landrigan PL: Skunk Associate Human Rabies. JAMA 222: 44, 1972.

4. Rosman MP, Hochberg F, and Richardson EP Jr: Coma in a 13 year old girl (SSPE) Case Records of the Massachusetts General Hospital. New Eng J Med 291:141-149,1974.

5. Hochberg F, Fisher CM, and Roberson GH: Spontaneous subarachnoid hemorrhage due to rupture of a normal intracerebral vessel. Neurology 24:319-321, 1974.

6. Picard E, Richardson EP Jr, and Hochberg F: Progressive obtundation in a 43 year old man. Case Records of Massachusetts General Hospital. New Eng J Med 290:1130-1136, 1974.

7. Hochberg F, DaSilva AB, Galdabini J, Richardson EP Jr: Gastrointestinal involvement in von Recklinghausen's neurofibromatosis. Neurology 24:1144-1151, 1974.

8. Hochberg F, Lehrich JR, and Aronson BG: Reactivation of experimental allergic encephalomyelitis using repetitive herpes simplex injections. Neurology 24:384, 1974.

9. Hochberg F, Nelson K, and Jansen W: Influenza type B associated encephalopathy. The 1971 Chicago outbreak of Reye's syndrome. JAMA 231:817-821, 1975.

10. Kistler JP, Hochberg F, Brooks BR, Richardson EP Jr, New PFJ, and Schnur J: Computerized axial tomography (CT scan), A clinicopathological correlation. Neurology 25:210-219, 1975.

11. Hochberg F, and LeMay M: Arteriographic correlates of handedness. Neurology 25:218-222, 1975.

12. Hochberg F, Bean SC, Fisher CMF, Roberson GH: Stroke in a fifteen year old girl secondary to terminal carotid dissection. Neurology 25:725-729, 1975.

13. New PFJ, Scott WR, Schnur JA, Davis KR, Taveras JM and Hochberg F: Computed tomography (CT) with the EMI Scanner in the diagnosis of primary and metastatic intracranial neoplasms. Radiology 114:75-87, 1975.

14. Kopp N, Hochberg F, Richardson EP Jr: La myelitie necrotique subaigue: De Foix et Alajouanine. A prospoe d`une observation anatomoclinique. Lyon Medical 234 (18):519-527, 1975.

15. Feorino P, Hochberg F, Humphrey D, and Chilocote R: Mononucleosis associated subacute sclerosing panencephalitis. Lancet 2:530-532, 1975.

16. Martuza RL, Shamberger RC, Phillips JP, Kornblith PL, Dohan FC Jr, and Hochberg F: A lymphocyte dependent antibody assay for detection of antibodies to human glioma cell. Surgical Forum 26 Cong Amer College of Surgeons, October, 1975.

17. Lehrich JR, Aronson EG, Hochberg F: Demyelinative myelinative myelopathy in mice induced by the DA virus. J Neurol Sci 29:149-160, 1976.

18. Hochberg F, Lehrich JR, Richardson EP Jr, et al: Mononucleosis-associated subacute sclerosing panencephalitis. Acta Neuropath (Berl) 34:33-40,1976.

19. Hochberg F, Linggood R, Wolfson L, et al.: Quality and Duration of survival in glioblastoma multiforme. JAMA 24:1016-1018, 1979.

20. Hochberg F, and Wolfson L: Discontinuous horizontal SDS acrylamide gel electrophoresis of cerebrospinal fluid. Science Tools 26:44-46, 1979.

21. LeMay M, and Hochberg F: Ventricular differences between hydrostatic, hydrocephalus and hydrocephalus ex-vacuo by computerized tomography. Neuroradiology 17:191-195, 1979.

22A. Safdari H, Hochberg F, Richardson EP Jr: Histological correlations with survival in malignant gliomas, Acta Neurochir [suppl] Wien 28(2): 485-488 (1979).

22B Safdari H, Hochberg FH, Richardson EP Jr.

Prognostic Value of Round Cell (Lymphocyte) Infiltration in Malignant Gliomas. Surg. Neurol 23:221-226, 1985.

23. Hochberg F, Slotnick B: Neuropsychological impairment in astrocytoma survivors. Neurology 30:172-177, 1980.

24. Hochberg F, and Pruitt A: Assumptions in the radiotherapy of glioblastoma. Neurology 30:907-911, 1980.

25. Davis SM, Ackerman RH, Correia JA, Alpert NM, Hochberg F et al: (PET scanning of Malignant Brain Tumors), Neurology 31:107-108, 1981.

26. Hochberg F, Parker L, Takvorian R, Canellos GP and Zervas NT: High-dose BCNU with autologous bone marrow rescue for recurrent glioblastoma. J Neurosurg 54:455- 460,1981.

27. Beal MD, Kleinman GM, Ojemann RG, and Hochberg F: Gangliocytoma of third ventricle: Hyperphagia, somnolence, and dementia. Neurology 31: 1224-1228, 1981.

28. Kleinman GM, Hochberg F, Richardson EP Jr: Systemic metastases from medulloblastoma: Report of cases and review of the literature. Cancer 48:2296- 2309, 1981.

29. Whitmore E, Hochberg F, Wolfson L, Royalty J, and Taft P: Quantitative Cytocentrifuge in the evaluation of cerebrospinal fluid (CSF): ACTA Cytologica 26:847-850, 1982.

30. Takvorian R, Parker LM, Hochberg F, Canellos GP: Autologous Bone Marrow Transplantation: Host Effects of High Dose BCNU. Jnl. Clin Oncology Vol 1, No 10, (Oct), 1983.

31. Ross RR, Kapp JP, Hochberg F, Krull IS: Solvent Systems for intra carotid BCNU infusion: Journal of Neurosurgery, Vol 12 (5):512-514, 1983.

32. Krull IS, Hochberg F, and Sternson LA: Trace Analysis for Cis-platinum anti-cancer drugs via liquid chromatography-electrochemical detection (LCED): Journal Chrom. Sci 21:166, 1983.

33. Krull IS, Ding XD, Selavka C, Hochberg F: An LCEC Assays for the Trace Analysis of CIS-platinum anti- cancer drugs: Current Separations, Bioanalytical systems, Inc., 5(1):14,1983.

34. Hochberg F, Leffert RD, Heller MD and Merriman L: Hand Difficulties Among Musicians. JAMA Vol. 249, No 14, 1849-1872, April, 1983.

35. Hochberg F, Poletti C, Krull IS, Strauss J: Analysis and Distribution of 1,3-Bis (2 chloroethyl)-1- nitrosourea (BCNU) in Biological Specimens. Neurosurgery 13:1303, 1983.

36. Hochberg F, Miller G, Schooley R et al: Epstein-Barr Virus Related Central Nervous System Lymphoma. NEJM 309:745-748, 1983.

37. Beal F, Richardson E, Brandsetter R, Hedley-White T, Hochberg F: Localized brainstem hypoxia-Ondine's curse after near drowning. Neurology 33:717-721, 1983.

38. Krull IS, Ding XD, Braverman S, and Selavaka C, Hochberg F, and Sternson LA: Trace analysis for CIS- platinum anti-cancer drugs via liquid Chromatography- electrochemical detection (LCEC): J Chrom Sci 21:166, 1983.

39. Duffy, F., Sandini, G., Hochberg, F., Burchfiel,D

Tumor detection from topographic maps of long latency evoked potentials: Spatial trajectory analysis and cross correlational analyses. Electroencephalography and clinical neurophysiology, June, 1984.

40. Hochberg F, Toniolo P, and Cole P: Head Trauma and seizures as risk factors of glioblastoma. Neurology 34:(11)1511-1514, 1984.

41. Greenberg DB, Hochberg F, Murray GB: The theme of death in complex partial seizures. Am J Psych 41:12, 1587-1589, 1985.

42. Jennings M, Hochberg F, Gelman R: Intracranial germ- cell tumors: National history and Pathogenesis. J. Neurosurg. 63:155-167, Aug, 1985.

43. Hochberg F, Pruitt A, DeBrun G, Davis K: The rationale and methodology for intra-arterial chemotherapy with BCNU as treatment for glioblastoma. J. Neurosurg. 63:876-880,1985.

44. Busis NA, Hochberg FH: Familial Syringomylia. J. Neuro, Neurosurg, Psychiatry 48(9) 936-938, 1985.

45. Mechanick JI, Hochberg F, LaRocque A: Hypothalamic Dysfunction following whole brain irradiation: An early marker of radiation toxicity. J. Neurosurg 65:490-494, 1986.

46. Rosenberg NL, Hochberg F, Miller G, Kleinschmidt- Demasters BK: Primary Central Nervous System Lymphoma Related to Epstein-Barr Virus in a Patient with AIDS. Ann Neurology 20:98-102, 1986.

47. Henrikson B, Hochberg F: Pseudotumor Cerebri: Management of "Benign" intracranial hypertension. Part I. Primary Cancer and Care. pp. 59-67, January, 1986

Henrikson B, Hochberg F: Pseudotumor Cerebri: Management of "Benign" intracranial hypertension. Part II Primary Cancer and Care. pp. 8-12, February, 1986.

48. Merriman L, Newmark J, Hochberg F, Shahani B, Leffert R: A focal Movement Disorder of the Hand in Six Pianists. Medical Problems of Performing Artists. Vol 1. No 1., pp 17-19, 1986.

49. Hochberg, F.: A 64 Year Old Man with Gait Disorder and Exophthalmus, (Epidural Lymphoma) CPC, NEJM, Vol.315, No.22, pp. 1401-1409, 1986.

50. Newmark J, Hochberg F: Isolated Painless Manual

Incoordination in 57 Musicians. J Neuro, Neurosurg, and Psych. 50:291-295. 1987.

51. Newmark, J., Hochberg, F.: "Doctor, It Hurts When I Play:' Painful Disorders Among Instrumental Musicians. Medical Problems of Performing Artists. Hanley and Belfus, Inc. Vol 2, No 3, pp. 93-97, September, 1987.

52. Hochberg FH, Lavin P, Portney R, Roberts D, Tinney C, Hottleman K, Wanger F, Newmark J, Cavanaugh K, Noonan M: Topical Therapy of Localized Inflammation in Musicians: A Clinical Evaluation of Aspercreme Versus Placebo. Medical Problems of Performing Artists. Hanley and Belfus, Inc. Vol 3 No 1, 9-18, March, 1988

53. Hochberg FH, Miller D: Primary Central Nervous System Lymphoma. J Neurosurg 68:835-853, 1988.

54. Bashir R, Hochberg FH, Linggood R, Hottleman, KH: Pre- irradiation internal carotid artery BCNU in treatment of glioblastoma multiforme. J Neurosurg 68:917-919, 1988.

55. Maciewicz R, Chung RY, Strassman A, Hochberg F. et al:

Relief of vascular headache with intravenous lidocaine:Clinical observations and proposed mechanisms. Clinical Journal of Pain 4:11-16, Raven Press, New York, 1988.

56. Griffith JL and Hochberg FH: Anorexia and Weight Loss in Glioma Patients. Case Reports. Psychosomatics. 29(3)335- 337, Summer, 1988.

57. Bashir R, and Hochberg FH: Paraneoplastic Neurological Syndromes. Cancer Investigations 6(1) 117-118, 1988.

58. Palmer E, Henrikson B, McKusick K, Strauss HW, Hochberg FH: Pain as an indicator of bone metasasis. ACTA Radiologica 29:445-449, 1988.

59. Heros DO and Hochberg FH: Treatment of esthesioneuroblastoma with chemotherapy. Report of two cases. J Neurooncol 6:141-145, 1988

60. Gabbai AA, Hochberg FH, Linggood R: High Dose methotrexate therapy of primary brain lymphoma. J Neurosurg, 70:190-194, February, 1989.

61. Allard JG and Hochberg FH: MRI in a Family with Hereditary Cerebral Arteriovenous Malformations. Archives of Neurology. 46:184-187, 1989.

62. Hochberg FH, Toniolo P, Cole P: Nonoccupational Risk Indicators of Glioblastoma in Adults.

J Neuro-oncol. 8:55-60, 1990.

63. Bashir R, Hochberg FH, Singer RH: Detection of Epstein-Barr Virus by In Situ Hybridization: Progress Toward Development of a Non-Isotopic Diagnostic Test. Amer. Jnl. Path. 135:1035-1043, 1989.

64. Bashir RM, Harris NL, Hochberg FH, Singer RM.: Detection of Epstein-Barr Virus in CNS Lymphomas by In-Situ Hybridization. Neurology 39: 813-817, 1989.

65. Cohen LG, Hallett M, Geller B, Hochberg FH: Treatment of Focal Dystonias of the Hand With Botulinum Toxin Injections. Jnl Neurol. Neurosurg Psychiat

52:355-363, 1989.

66. Bashir R, Freedman A, Harris N, Nadler L, Hochberg F.

Immunophenotypic Profile of CNS Lymphoma: A Review of Eighteen Cases. Jnl. Neuro-Oncol. 7 (3):249-254, 1989.

67. Lassoff SJ, Hochberg FH, Skates S: Low Grade Gliomas- Assumptions in the Evaluation of Low-Absorption CT Masses. (Jnl. Neurosurg submitted).

68. Louis D, Hochberg FH: Cerebral primitive neuroectodermal tumor in an adult, with spinal cord metastasis after 18- year dormancy. Jnl. Neuro-Oncol. 9:77-80, 1990.

69. Bashir R, Hochberg FH, Harris NL, Demmenga D, Purtilo D: Variable Expression of EBV Genome as Demonstrated by In Situ Hybridization in CNS Lymphoma in Immunocompromised Patients. Modern Pathology, Vol. 3, No. 4, pp. 429-434, 1991.

70. Bashir R, Coakham H, Hochberg FH: Expression of LFA-1/

ICAM-1 in CNS Lymphomas: Possible Mechanism for Lymphoma Homing into the Brain. J. Neuro-Oncol. 12:103-110, 1992.

71. Hochberg FH, Harris SU, Blattert TR. Occupational Hand Cramps: Professional Disorders of Motor Control. Hand Clinics of North America 6 (3) 417-428, August 1990.

72. Gruber ML, Hochberg FH. Visual Scotomata From Lupus Anticoagulant in a Patient with Lymphoma in Remission. Jnl. Neuro-Oncol. 11:77-79, 1991.

73. Hochberg FH : Modalities of Cisplatin Administration to Brain Tumors. Cancer Investigation 7 (6):611-612, 1989.

74. Hochberg FH, Loeffler JS, Prados M: The Therapy of Primary Brain Lymphoma. Jnl. Neuro-Oncol. 10:191-201, 1991

75. Loeffler JS, Alexander E III, Hochberg FH et al: Clinical Patterns of Failure Following Stereotactic Interstitial Irradiation For Malignant Gliomas. Int. Jnl. Rad. Oncol. Biol Phys. pp. 1455-62, Dec. 19, 1990

76. Hochberg FH, Glass J. Primary Central Nervous System Lymphoma: Diagnosis and Treatment. Neurology Chronicle 1:1-5, 1991.

77. DeVeber G, Hochberg FH. Determinants of Prognosis in Brain Stem Glioma. Neurosurgeons (Japan)(Proceedings of the Japan Neurosurgical Society). 10:49-54, 1991.

78. Leifer D, Hochberg FH. Post-Traumatic Pontine Truncal Sensory Level. (Arch. Neurology 48:1216, 1991)

79. Bakshi R, Ducatman A, Hochberg FH. Glioblastoma in New England Ophthalmologists (Letter) NEJM 324:1440-41, 1991.

80. Hildebrand J, Thomas DGT et al. Report of a Workshop Sponsored by the European Organisation for Research and Treatment of Cancer (EORTC) on the Treatment of Primary Malignant Brain Tumours. Jnl Neuro. Neurosurg and Psych. 54:182-183, 1991.

81. Glass J, Hochberg FH, Gruber ML, Louis DN, Smith D, Rattner B. The Treatment of Oligodendrogliomas and Mixed

Oligodendroglioma-Astrocytomas with PCV Chemotherapy. J. Neurosurg. 76:741-745, 1992.

82. Bakshi R, Hochberg FH, Louis D. Chronic Leukoencephalitis

Arch. Neurol. July, 1992 submitted.

83. Huang CC, Lu CS, Chu NS, Hochberg FH, Lilienfeld D, Calne DB. Pathogenesis of Idiopathic Parkinsonism. in Rinne UK, Yanagisawa N. Controversies in the Treatment of Parkinson's Disease. pp. 7-13, PMSI Japan, Tokyo 1992.

84. Glass J, Hochberg FH, Miller DC. Intravascular Lymphomatosis. Cancer 71:3156-3164, 1993.

85. Brouillet EP, Shinobu L, McGarvey U, Hochberg FH, Beal MF. Manganese Injections Into the Rat Striatum Produces Excitotoxic Lesions by Impairing Energy Metabolism.

Experimental Neurology 120, 89-94, 1993.

86. Miller DC, Hochberg FH, Harris N.L; Gruber ML, Louis DN, Cohen H.Pathology with Clinical Correlations of Primary Central Nervous System Lymphoma-The Massachusetts General Hospital Experience(1958-1989). CANCER 74:1383-1397, 1994

87. Aronin H, Hochberg FH, Rosen B, et al. Functional MRI Mapping of Blood Volume in Primary Brain Tumors. Acta. Radiol Scand.(accepted 1994)

88. Glass J, Hochberg FH, Gruber ML. Fluosol-BCNU Chemotherapy of Recurrent Malignant Astrocytoma.Jnl. Neuro-Onc Oct. 1994

89. Nitschke M, Hochberg FH, Dropchko E. Paraneoplastic Opsoclonus-Myoclonus: Improvement after Protein A Column Therapy. NEJM (In print December 1994)

90. Bashir R, Luka J, Cheloha K, Kieff E, Chamberlain M, Hochberg FH, Expression of the Epstein-Barr Membrane Protein, LMP, in AIDS-related Primary Brain Lymphoma. Accepted Neurology, 1994

91. Nitschke M, Hochberg FH, Miller G, Katz B. Polymerase Chain Reaction Demonstration of Epstein-Barr Virus Genome in Subacute Encephalitis

92. Pardo FS, Aronin HJ, Kennedy D, Skates S, Paiva K, Linggood RM, Okunieff P, Schmidt EV, Hochberg FH, Fischman AJ, Rosen BR. Functional Cerebral Imaging in the Evaluation and Radiotherapeutic Planning of Patients with Malignant Glioma. Int. Jnl Radio. Biol. 30:663-669, 1994.

93. Brouillet E, Jenkins B, Michel R,...Hochberg FH. In Vivo Quantification of Cerebral Manganese Concentrations using Magnetic Resonance Imaging. Proceedings of the First International Manganese Conference, Chantilly, France. November 1992.

94. Wei MX, Tamiya T, Chase M, Efstathios JB, Chang TKH, Kowall NW, Hochberg FH, Waxman DJ, Breakefield XO, Chiocca EA. Therapy of Meningeal Neoplasia in Mice with the Cyclophosphamide-Activating Cytochrome P450 2B1 Gene.

Human Gene Therapy 5:969-978, August 1994

95. Hiesiger EM, Green SB, Shapiro WR, Burger PC, Selker RG,

Mahaley MS, Ransohoff J II, VanGilder JC, Mealey J Jr., Robertson JT, Hochberg FH, Young R. Results of a Randomized Trial Comparing Intra-arterial Cisplatin and Intravenous PCNU for the Treatment of Primary Brain Tumors in Adults: Brain Tumor Cooperative Group Trial 8420A. Jnl Clin Oncology 10/93.

96. Huang CC, Lu C-S, Chu N-S, Hochberg FH, Lilienfeld D, Olanow W, Calne DB. Progression after Chronic Manganese Exposure. Neurology 43:1479-1483, 1993.

97. Nitschke M, Hochberg FH, Dropcho E. Opsoclonus-Myoclonus of Small Cell Lung Cancer: Improvement After Protein A Column Immunoadsorption Therapy. NEJM. Letter 1994.

98. Glass J, Gruber ML, Cher L, Hochberg FH. Preirradiation Chemotherapy of primary central nervous system lymphoma: Long term outcome. J. Neurosurg 81:188-195, 1994.

99. Valenzuela R and Hochberg FH Human Manganese Exposure. Submitted to Brit Jnl Occup Medicine 1994

100. Gasser T, Bove C. Ozelius L, Hallett M, Charness M,Hochberg F, Breakefield XO. Haplotype Analysis in Ashkenazi Jewish Patients with Occupational Hand Dystonia. Submitted Movement Disorders, 1995.

101. Cher L, Teruya J, Hochberg FH, Schmahmann J et al. Therapy of Paraneoplastic Neurologic Syndromes with Immunoadsorption (Protein A)Cancer, in press 1995 (April)

102. Hochberg FH, Cher L. Primary Central Nervous System Lymphoma. Review of DeAngelis article. Oncology. January 1995. Vol 9 No.1. 76-77.

103. Bashir R, Hochberg FH, Wei M. The role of EB virus in the etiology of Primary brain Lymphoma. Jnl Neuro-Onc 1995 (invited and accepted)

104. Hochberg FH, Prados M, Russell C, Weissman D et al. Treatment of Recurrent malignant glioma with BCNU-Fluosol and oxygen inhalation. A phase I-II study. Jnl Neuro-onc 4/1995.

IN PREPARATION

A. Hochberg FH, Caviness V, Metz R, Bruno G. Registered Echo- Planar MRI, Standard MRI and FDG PET in the assessment of Glioma.

B. Hochberg FH, Villacencia. Occupational Disorders of Motor Control. NEJM 1994 (invited)

C. Hochberg FH, Cosgrove R, Valenzuela R. A miniature radiosurgery device in the treatment of brain metastases. A Phase I trial of 14 patients. Jnl. Neurosurg. 1994.

D. Bashir R, Ruby E, Hochberg Fred H. Hochberg, M.D.

Host Immune Response to Primary CNS Lymphoma. Neurology 1995

E. Alderson L, Fetell M,Sisti M, Hochberg Fred H. Hochberg, M.D.

Cohen M, Louis D. Sentinel Lesions in Primary CNS lymphoma. Journal Neurology, Neurosurg, Psychiat. 1995

BOOKS

1. Rottenberg, D.A. and Hochberg, F. eds: Neurologic Classics in Modern Translation. Hafner Press, Macmillan, June 1977.

2. Hochberg FH, Perkin GD. Miller DC. Atlas of Clinical Neurology. Gower (London) 1992.

CHAPTERS

1. Hochberg, F.: Prognosis, Contemporary outcomes of Disease, glioblastoma, Chapter 32, Section II, page 128- 132, James F. Fries, M.D. and George E. Ehrlich, M.D. (eds.), The Charles Press Publishers, Bowie, M.D. 1981.

2. Hochberg F: Neurologic aspects of systemic tumors. In principles of internal medicine, Update I, Isselbacher, Adams, Braunwald, Petersdorf, Wilson and Martin (eds.),9th edition, 10th edit, 11 edit. 12 edit. McGraw-Hill Co.,New York, 1981-1993 (13th ed).

3. Takvorian T, Hochberg F, Canellos F, Parker, L., Zervas, N., and Frei, E.: The toxicity of high-dose BCNU with autologous marrow support, in Nitrosoureas: Current status and new developments, Prestakyo, A.W., et al. (eds.), Academic Press Inc., New York, NY, 1981.

4. Hochberg, F., Forman, A.: Central Nervous System Lymphoma, Your patient and Cancer. pg. 27, November, 1983.

5. Fingert, H., Hochberg, F.,: Megadose chemotherapy with Bone marrow rescue: Progress in experimental brain tumor research, Rosenblum, M.D. and Wilson, C.B. Vol. 2:67-78, (Karger, Basel), 1984.

6. Jennings, M., Gelman, R., Hochberg, F.: Intracranial germ cell tumors: Natural History and Pathogenesis. in Neuwald, E.A. DIAGNOSIS AND TREATMENT OF INTRACRANIAL GERM CELL TUMORS. Williams and Wilkins, Baltimore, 1984.

7. Hochberg, F., Pruitt, A., Beck, DO., DeBrun, G., Davis K: The rationale and methodology for intra-arterial chemotherapy with BCNU as treatment for glioblastoma in Infusional therapies in cancer treatment. Howell, ST M. Nijhoff (Boston), 1984.

8. Krull IS, Ding XD, Selavka C, Hochberg F: Liquid Chromotographic determinations of Cis platinum Anti-surveys in Biochemistry and analysis (Vol 14) edit E.Reid. Plenum Press, London. 1985.

9. Hochberg, F., Heros, D. Regional Infusion For Brain Tumors. Cancer Chemotherapy by Infusion, Lokich J. CHAP 36:467-478, 1987.

10. Heros, D., Hochberg, F. Intraventricular Chemotherapy for Leptomeningeal Carcinoma. Cancer Chemotherapy by Infusion, Lokich J. CHAP 39:525-537, 1987.

11. Hochberg FH, Lavin, Portney, Roberts D, Tinney C,Hottleman K, Wanger F, Newmark J, Cavanaugh K, Noonan M: Topical therapy of localized inflammation in musicians: A clinical evaluation of Aspercreme vs. Placebo. Schmerz und Sport. Spintge and Droh (eds) pp: 135-149, 1988

12. Hochberg FH, Lederman RJ: The Upper Extremity Difficulties of Musicians. Rehabilitation of the Hand. Hunter JM. CV Mosby St. Louis, 1989) 99:1197-1209, 1990, 1993

13. Hochberg FH and Gabbai AA: Risk Factors in the Development of Brain Tumors in Wilkins Ed, Neurosurgical Update. 8:1, January 1990.

14. Hochberg FH, Harris SU, Blattert T: Occupational Hand Cramps - Professional Disorders of Motor Control. ed. Amadio. Hand Clinics of North America. 6:417-428, 1990

15. Hochberg FH and Gruber ML. Primary Central Nervous System Lymphoma. Current Therapy in Neurologic Disease-4. ed. Johnson. 1993.

16. Chu N-S, Hochberg FH, Calne D, Olanow CW. Neurotoxicology of Manganese in Chang LW and Dyer RS. Handbook of Neurotoxicology, Dekker, New York 1995.

17. Hochberg FH, Pruitt AA. Tumors of the Nervous System. In Harrison Textbook of Internal Medicine. Edit 13, 1994. (Edit. Isselbacher K).

18. Rock JP, Cher L, Hochberg FH, Rosenblum ML. Primary Central Nervous System Lymphoma. Youmans. Neurosurgery, 1995; and Black PM and Loeffler J. 1995.

19. Valenzuela R and Hochberg FH. Methotrexate Toxicity in Spencer PS and Schaumberg Experimental abd Clinical Neurotoxicology. Oxford Press 1996

ABSTRACTS

1. Brooks, B.R., Hochberg, F.J., Hauptil, J., Kornblith, P.L.: Morphologic and kinetic analysis of explant cultures of 100 central nervous system biopsy specimens. The 50th Annual Meeting of the American Association of Neuropathologists, Boston, Massachusetts, June 1974.

2. Hochberg, F.H., Schur, P.H., Kornblith, P.L., Freedman, A., Whitman, B.O.: Glioblastoma cell line specific antisera. American Federation of Clinical Research, May 1975 and American Association of Neuropathologists,June 1975.

3. Hochberg, F.J., Hochberg, C.N., Meckler, R., Feorino, R.: Mononucleosis associated encephalitis-report of 28 cases and review of the literature. Fourth Pan-American JCongress of Neurology, Mexico City, October, 1975.

4. Hochberg, F.H., Richardson, E.P., Astrom, E.E., Lehrich, J.R., Feorino, P., and Crumpacher, C.: Mononucleosis-associated SSPE; 50th Annual Meeting American Association of Neuropathologists., Boston, June 1974, J. Neuropath. Exp. Neurol. 34: 88,, 1975.

5. Hochberg, F.H., Mathieson, J. and Barlow, C.: Childhood multiple sclerosis-report of 18 cases; 4th Pan Americ Cong. Neurol., Mexico City, October, 1975.

6. Hochberg, F.H., Pruitt, A.: Assumptions in the radiotherapy of malignant glioblastoma. American Academy of Neurology, Chicago, April 1979.

7. Hochberg, F.H., Safdari, H. and Rabinowicz, T.: Histologic correlated of survival in malignant gliomas. Inter. Symposium on Multidisciplinary Aspects of Brain Tumor Therapy. Brescia, Italy, June 8-10, 1979.

8. Hochberg, F.H., Cole, P.: Epidemiology of brain tumors: A case-control study. Inter. Symposium on Multidisciplinary Aspects of Brain Tumor Therapy. Brescia, Italy, June 8-10, 1979.

9. Hochberg, F.H., and Slotnick, F.: Diffuse Cortical Dysfunction in Glioblastoma survivors. Inter. Symposium on Multidisciplinary Aspects of Brain Tumor Therapy. Brescia, Italy, June 8-10, 1979.

10. Hochberg, F.H., Parker, L.M., Takvorian, T., Canellos, G., and Zervas, N.T.: Recurrent glioblastoma multiforme treatment using high-dose BCNU with autologous bone marrow rescue. Autologous bone marrow rescue in the treatment of glioblastoma multiforme. Inter. Symposium on Multidisciplinary Aspects of Brain Tumor Therapy. Brescia, Italy, June 8-10, 1979.

11. Hochberg, F.H., Parker, M.M., Takvorian, T., Canellos, G., and Zervas, N.T.: Recurrent glioblastoma multiforme treatment using high-dose BCNU with autologous bone marrow rescue. American Academy of Neurology, New Orleans, Louisiana, April 29 - May 3, 1980.

12. Hochberg, F.H., Wolfson, L., Royalty, J., Whitmore, E., and Taft, P.: Quantitative cytocentrofugation in the evaluation of cervical spinal fluid (CSF). American Academy of Neurology, New Orleans, Louisiana, April 29 - May 3, 1980.

13. Hochberg, F.H., Parker, L.M., Takvorian, T., Canellos, G., and Zervas, N.T.: High Dose BCNU with autologous bone marrow rescue for recurrent glioblastoma multiforme. American Association of Neurological Surgeons. New York, New York, April 20-24, 1980.

14. Takvorian, T., Canellos, G., Parker, L., Hochberg, F., Zervas, N.T., Frei, E.: The toxicity of high dose BCNU with autologous marrow support. The Bristol Laboratories Forth Annual Symposium on Nitrosoureas: Current Status and new Developments. September 35-26, Detroit, Michigan, 1980.

15. Davis, S.M., Ackerman, R.H., Correia, J.A., Alpert, N.M., Hochberg, F.H., Buonanno, F., Finkelstein, G.L., Brownell, G.L., and Taveras, J.M.: Positron imaging of CBF and metabolism inpatients with brain tumors. American Academy of Neurology. Toronto, Canada, April 30 - May 2, 1981.

16. Krull, IS., Strauss, J., Hochberg, F.H.,: An improved trace assay for N-nitrosoureas from biological media. Conference on Analytical Chemistry and Applied Spectroscopy, Atlantic City, N.J., March 9-13, 1981.

17. Kistler, J.P., Buonanno, E.S., Brady, T.J., Pyketts, I.L., Hochberg, F.H., Parker, S., New, P.F.J., Hinshaw, W.S., Goldman, M.R., and Pohost, G.M.: Clinical experience using nuclear magnetic resonance (NMR) imaging in cerebral vascular and other CNS diseases: Comparison with x-ray CT and pathology. American Academy of Neurology, 34th Annual Meeting, Washington, D.C., April 25 - May 1, 1982.

18. Kwiatkowski, D. and Hochberg, F.H.: Meningeal cancer - Evaluation of published concepts. American Academy of Neurology, 34th Annual Meeting, Washington, D.C., April 25 - May 1, 1982.

19. Hochberg, F.H., Cole, P., Salcman, M., Kadish, S.P., Glicksman, A., Saunders, R., Toniolo, P. and Taylor, L.: Risk factors in glioblastoma development. American Academy of Neurology, 34th Annual Meeting, Washington, D.C., April 25- May 1, 1982.

20. DeBrun, G.M., Davis, D.R., Hochberg, F.H., and Martin, J.B.: Superselective injection of BCNU through a latex calibrated leak balloon. American Journal of Neuroradiology, 1982.

21. Kistler, J.P., Buonanno, E.S., Brady, T.J., Pykett, I.L., Hochberg, F.H., Parker,S., New P.F.J., Hinshaw, W.So, Goldman, M.R. and Pohost, G.M.: Clinical Experience Using Nuclear Magnetic Resonance (NMR) Imaging in cerebral vascular and other CNS diseases: Comparison with x-ray CT and pathology. Neurology, New York, NY, April 1982.

22. Davis, S.M., Ackerman, R.H., Correia, J.A., Alpert, N.M., Hochberg, F.H., Buonanno, F., Finkelstein, S., brownell, G.L., and Taveras, J.M.: Positron imaging of CBF and metabolism in patient with brain tumors. American Academy of Neurology, 1982.

23. Cohen, L., Hallett, M., Geller, B., Dubinsky, R., Meer, J., Baker, M, Hochberg, F.: Treatment of Focal Dystonias of the Hand with Botulinum Toxin Injection. Neurology, March 37 (Supple 1) 123-124, 1987.

24. Bashir, R., Hochberg, F., Oot, R. Regrowth Patterns of Glioblastoma Multiforme Following Surgery and Radiotherapy. Neurology, March 37 (Suppl 1) 334, 1987.

25. Bashir, R., Hochberg, F. Preirradiation Intracarotid Artery BCNU for Treatment of Malignant Gliomas. Neurology, March 37 (Suppl 1) 336, 1987.

26. Kerman KL, Hochberg FH, Caviness VS. Branched Chain Amino Acid Supplements in the Treatment of Multisystem Atrophies: A Kinematic Study. Amer. Acad of Neurology, 1989.

27. Lassoff S, Hochberg FH, Skates S. Low Grade Gliomas-Assumptions in the Evaluation of Low Absorption CT Masses. Amer. Acad. Neurology, 1989.

28. McKusick KA, Fischman AJ, Hochberg FH et al. TL-201 and F-18 Deoxyglucose in Detection of Recurrent Primary Brain Tumor. Soc. of Nuclear Med. Cinn, Ohio 1991.

29. Glass, J; Gruber ML, Hochberg FH. Chemotherapy (PCV) of Homogenous and Mixed Oligodendroglioma. Tenth International Brain Tumor Meeting (Asilomar 1991)

30. Hochberg FH, Glass J, Prados M. et al... Fluosol/BCNU Chemotherapy of Recurrent Glioma. Tenth International Brain Tumor Meeting (Asilomar 1991)

31. Miller DC, Hochberg FH, Harris NL, Gruber ML, Louis D CNS Lymphoma Update. Tenth International Brain Tumor Meeting Asilomar Calif. 1991.

32. Aronen HJ, Buchbinder BR, Hochberg FH et al. Comparison of Hyperscan Diffusion and Dynamic Susceptibility-Contrast CBV Imaging in Human Brain Tumors. Society for Magnetic Resonance in Medicine San Francisco, August 10, 1991.

33. Bashir R, Luka J, Cheloha K, Hochberg FH. Expression of EBV Transcribed Proteins in AIDS-Related CNS Lymphoma. American Academy of Neurology. 1993.

34. Glass J, Hochberg FH. Pre-Irradiation Chemotherapy of Primary Central Nervous System Lymphoma with CHOD and Methotrexate. AAN, 1993.

35. Aronen HJ, Provenzale JM, Goldberg IE, Thulborn KR, Gonzalez G, Hochberg FH et al. Comparison of Low and High Dose (0.1 and 0.3 MMol/kg Gadodiamide in Central Nervous System Lesions. Society of Magnetic Resonance in Medicine. Berlin, August 8, 1992.

36. Aronen HJ, Goldberg IE, Pardo F, Hochberg FH et al. Susceptibility-Contrast CBV Imaging: Clinical Experience in Brain Tumor Patients. Society of Magnetic Resonance in Medicine. Berlin, August 8, 1992. and New York 1993.

37. Zervas NT, Yanch J, Hochberg FH, Okunieff P. An Electron Accelerator Probe for Intraoperative Radiosurgery. International Radiosurgery, Stockholm Sept 1993 and Tenth International Brain Tumor Meeting, Norway Sept 1993.

38. Aronen HJ, Goldberg IE, Pardo FS and Hochberg FH. Multislice MRI CBV Mapping of Brain Tumors: A Comparison with PET Studies using FDG and CO. The Society of Nuclear Medicine. Toronto. June 1993.

39. Shustik C. Glass J, Gruber M, Hochberg FH. Treatment of Primary CNS Lymphoma with M-CHOP Followed by Craniual Irradiation. Lymphoma International Workshop. Lugano, Switzerland Sept 1993.

40. Glass J, Hochberg FH, Bashir R, Cher L. Insights Into Primary Lymphoma of the Nervous System. Third International (Julian Bloom) Neuro-oncology Conference (Invited Presentation). April 1993.

41. Hochberg FH, Cosgrove R, Valenzuela R, Zervas N, Rattner B, Pardo F. Miniature Intracranial X-Ray Probe for Radiosurgery.

Third International Neuro-Oncology Conference (Julian Bloom),

London April, 1993.

42. Cher L, Glass J, Hochberg FH. Therapy of Primary Central Nervous System Lymphoma with Methotrexate-Based Chemotherapy and Deferred Whole Brain Radiation Therapy.Abst 985 American Academy of Neurology, 1994.

43. Valenzuela R, Hochberg FH, Cosgrove R, Pardo F. Brachytherapy with a Miniature X-Ray source in Brain Metastases.Abst 362 vol44*a:217,1994 American Acad. of Neurology.AND Third International Neuro-Oncology Conf. Royal Marsden Hosp, London April 1993.

44. Teruya J, Hochberg FH, Valenzuela R et al Effectiveness of Protein A Column Treatment for Patients with Paraneoplastic Syndrome. Fifth Intl Congress World Apheresis Assoc.March, 1994.

45. Kanady K, Choi N, Efird J...Hochberg FH. Efficacy of Post- Operative Fractionated External Beam Radiation in the Treatment of Solitary NSCLC Brain Metastasis. ASTRA 1994.

46. Alderson L, Hochberg FH. Primary Central Nervous System Lymphoma. Abstracts of Clinical Care Guidelines Vol 6 No.1 PP10,12. Jan 1994.

47. Wei MX, Tamiya T, Chase M...Hochberg FH. Therapy of Meningeal

Neoplasia in Mice with the Cyclophosphamide-Activating Cytochrome P-450 2B1 Gene. In Growth Control in CNS Tumors. Boston, Massachusetts May 1994.

48. Rave T, Bashir R, Bennett DR, Hochberg FH. CNS Lymphoproliferative Disease Post Autologous Bone Marrow Transplantation. Amer. Acad of Neurol 1995.

49. Bashir R, Bierman P, Hochberg FH. Host Cellular Immune Response to Primary CNS Lymphoma. Amer. Acad Neurol 1995.

50. Valenzuela, R; Hochberg FH. Multifocal Inflammatory Leukoencephalopathy associated with Levamisole and 5-FU; Neurosurgery 1994.

51. Lev MH, Schaefer PW, Sorensen...Hochberg FH et al. The Clinical Uitlity of Functional Magnetic Resonance Imaging of Cerebral Blood Volume in the Evaluation of Intracranial Tumors. Amer Soc Neuroimaging 1995.

52. Nitschke M, Schotz J, Vieregge P, Komp D, Hochberg FH. Paraneoplastic Opsoclonus-Myoclonus Syndrome-Two unusual Cases. J. of Neuro-oncology 27 No 1, 1994 The First Congress of the European Association for Neuro-Oncology Maastricht 1994.

53. Sorensen AG, Kulke S, Aronen H...Hochberg FH...Rosen BR. Relative Cerebral Blood Volume Maps Can Distinguish Tumor Recurrence from Radiation Necrosis. Amer. Soc. Neuro-Imaging 1995.

54. Bruening R, Hochberg FH, Kwong K, Cher L, Valenzuela R, Weisskoff R, Brady T, Rosen RB. Changes in the Blood Brain Barrier (BBB) Leakage measured with MRI using Echo Planar Imaging (EPI) in Human Glial Tumors following Injections of Steroids. ASNR 1994 Nashville, Tn.

55. Adams RD, Hochberg FH, Vonsattel JPG. Dr. Th. Rabinowicz in Journal Neuropathology and experimental Neurology. 1995