
Welcome to the Particles NewsLetter Web Site
Issue: Number 25 January 2000
Editor: Janet
Sisterson Ph.D., NPTC
|
Introduction | Facilities
| Patients | HCL
HomePage
The
is the current issue Particles Newsletter
( Number 25 January 2000) in html format. There is also
a PDF
version and MS
Word available. See the Particles Newsletter Archives
Section for back issues.
Introduction
How important
is CME credit to PTCOG meeting attendees? This issue has been
raised several times at PTCOG Steering Committee meetings and
now we need input from the PTCOG community. We need to know how
many of you can attend a PTCOG meeting only if CME credit is offered.
We also want to know your thoughts on this matter. Please answer
this informal survey by contacting Janet Sisterson by one of the
methods given below, indicating how your decision to attend a
PTCOG meeting is influenced by the availability of CME credit.
Costs: At PTCOG
XIX, the Steering Committee decided that part of the registration
fee for PTCOG meetings would be used to help produce both Particles
and the abstracts of the PTCOG meetings. Only part of the costs
is covered in this way, so more financial help is needed from
the community. PTCOG is always happy to receive financial gifts;
all such gifts are deductible as charitable contributions for
federal income tax purposes. The appropriate method is to send
a check made out to the "Massachusetts General Hospital"
and sent to Janet Sisterson at the address given below. We thank
ZA Consulting and William Walker for their kind donations in support
of Particles.
Facility and
Patient Statistics: I continue to collect information about all
operating or proposed facilities. Please send me your information.
The latest published summary of the world-wide patient statistics
with detailed patient data through 1997 can be found in the following
reference:
"World wide
proton therapy experience in 1997." Author: J. M. Sisterson.
CP475, Application of Accelerators in Research and Industry, eds.
J. L. Duggan and I. L. Morgan, AIP Press, New York (1999), p959-962.
Copies available on request.
Particles on
the Internet: The URL for the Harvard Cyclotron Laboratory is:-
These contain
links to recent issues of Particles.
Other proton
therapy links:
- Northeast
Proton Therapy Center: http://www.mgh.harvard.edu/depts/nptc/nptc.htm
- CPO, Orsay,
France: http://www-sop.inria.fr/epidaure/personnel/bondiau/CPO_base/cpo_base.htm
- LLUMC, California:
http://www.llu.edu/proton
- U of California,
Davis: http://crocker.ucdavis.edu/cnl/research/eyet.htm
- Midwest Proton
Radiation Institute: http://www.iucf.indiana.edu
- National Association
for Proton Therapy: http://www.proton-therapy.org/
- Prolit - database
of particle radiation therapy: http://proton.llu.edu
- TRIUMF, Canada
protons: http://www.triumf.ca/welcome/proton_thrpy.html
- TRIUMF, Canada
pions: http://www.triumf.ca/welcome/pion_trtmt.html
- PSI, Switzerland:
http://www.psi.ch/
- Proton Oncological
Therapy, Project of the ISS, Italy: http://top.iss.infn.it
- TERA foundation,
Italy: http://www.tera.it
- GSI homepage:
http://www.gsi.de
- The Svedborg
Laboratory, Sweden: http://www.tsl.uu.se/
- Clatterbridge
Centre for Oncology: http://synaptic.mvc.mcc.ac.uk/simulators.html
- Tsukuba, Japan:
http://www-medical.kek.jp/index.html
- Tsukuba, Japan
- new facility plans: http://www-medical.kek.jp/devnewfac.html
- HIMAC, Chiba,
Japan: http://www.nirs.go.jp/ENG/particl.htm
(ENG case sensitive)
- NAC, South
Africa: http://www.nac.ac.za/~medrad/
ARTICLES
FOR PARTICLES 26
June 30 2000
is the deadline for news for Particles 26, the July 2000 issue.
I will send reminders by fax or e-mail.
Address all correspondence
for the newsletter to:
Janet Sisterson
Ph.D. Telephone: (617) 724-1942
Northeast Proton
Therapy Center Fax: (617) 724-9532
Massachusetts
General Hospital E-mail: jsisterson@partners.org
30 Fruit Street
Boston MA 02114
Articles for
the newsletter can be short but should NOT exceed two pages in
length. The best way to send an article is by computer. If you
mail or fax an article, remember that I scan them into the computer
so I need a good clean copy of any figures.
PLEASE, when
you send me a file by computer GIVE IT AN UNIQUE TITLE that will
indicate to me the source of the article. You have no idea how
many files I have on my computer that are called ptles24.doc or
something similar!!
PTCOG
BUSINESS and FUTURE PTCOG MEETINGS
|
Chair:
Michael Goitein
|
Secretary:
Janet Sisterson
|
|
Department
of Radiation Oncology
Massachusetts
General Hospital
Boston
MA 02114
|
Northeast
Proton Therapy Center
Massachusetts
General Hospital
Boston
MA 02114
|
Steering Committee
Members
|
USA
|
Europe
|
Russia
|
Japan
|
South Africa
|
|
W. Chu
|
U. Amaldi
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V. Khoroshkov
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K. Kawachi
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D. Jones
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|
M. Goitein
|
H. Blattmann
|
|
H. Tsujii
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|
|
D. Miller
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J.-L. Habrand
|
|
|
|
|
J. Sisterson
|
G. Munkel
|
|
|
|
|
James Slater
|
E. Pedroni
|
|
|
|
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A. Smith
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A. Wambersie
|
|
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H. D. Suit
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|
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L. Verhey
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The times and
locations of the next PTCOG meetings are as follows:
|
PTCOG
XXXII
|
Uppsala,
Sweden
|
April
16 - 19 2000
|
|
PTCOG
XXXIII
|
*** note
location change **
Berlin,
Germany
|
September
25 27 2000
|
|
PTCOG
XXXIV
|
Boston,
MA, USA
|
Spring
2001
|
PTCOG is very
grateful to all our colleagues in Berlin for agreeing at such
short notice to organize PTCOG XXXIII in September 2000.
Summary
of the Steering Committee Meeting,
PTCOG
XXXI
Tuesday
October 12 1999, Indiana, USA.
Present:
E. Blomquist, W. Chu, D. Errington, M. Goitein, E. Grusell, D.
Jones, S. Klein, R. Martin, D. Miller, E. Pedroni, J. Sisterson,
H. Suit, M. Wedekind, J. Wilson, L. Yonemoto.
1) Future meetings:
Definite Tentative
April 16 - 19
2000: Uppsala, Sweden Fall 2000: TERA; Lake Maggiore, Italy.
Spring 2001:
Boston, USA
Fall 2001: Tsukuba,
Japan
Spring 2002:
Berlin, Germany
No representatives
of the TERA collaboration attended this PTCOG meeting, so at this
time we could not establish whether they still wished to host
this meetings. As we subsequently learnt, they did not and we
are grateful to our German colleagues for agreeing to host this
meeting.
2) There will
be workshops held on Sunday April 16 2000 before the official
start of the Uppsala PTCOG meeting. One might be on Monte Carlo
methods. Several topics were suggested for focus sessions.
3) CME credit:
Susan Klein discussed the experience of offering CME credit at
this PTCOG meeting. The pre-requisites for providing CME credit
are determined by the institution offering it. At Indiana this
was the Medical School, who wanted the program fixed 6 months
ahead of time and insisted on looking after the registration.
Also, because the meeting is required to have a faculty, in essence
every speaker becomes a member of the faculty. Although there
were some problems, on the whole it seemed to work. The issue
is really important for physicians, particularly for those working
for HMOs. Jenny Wilson felt that in the future it would be essential
for PTCOG meetings to offer CME credit. Bill Chu was very concerned
that regulations might constrain the free discussions that are
possible at the present PTCOG meetings.
It was resolved
at present to:
- Let the host
institution decide whether to offer credit or not.
- Use disclosures
with discretion.
- Conduct a
survey via Particles to see how many people can attend ONLY
if CME credit is offered. See Page 1 of this issue of Particles.
4) Funding for
Particles. PTCOG needs to become more aggressive in collecting
the dues to fund the production of Particles, in seeking out gifts,
and in investigating ways electronic publishing.
PTCOG
XXXII
April
16-19 2000.
Uppsala,
Sweden
Uppsala
welcomes you with an atmosphere of tradition and inspiration!
For more than
500 years, Uppsala has provided an inspiring environment for the
advancement of science, literature and art. Carolus Linnaeus,
Ingmar Bergman and Dag Hammarsköld are among those who have lived
and worked here. Uppsala University was founded in 1477, and the
beautiful Main Building, was inaugurated in 1887. Today Uppsala
University has more than 30.000 registered students. In addition,
the Swedish University of Agricultural Sciences also resides in
Uppsala.
Also, when in
Uppsala, take the opportunity to visit the Dome of Uppsala, the
largest cathedral in Scandinavia. It was inaugurated in 1435 and
provides a very impressive example of gothic architecture. Other
sights are the Gustavianum with its Anatomical Theatre and the
art cabinet of Augsburg, the University Library Carolina Rediviva
with the Silver Bible, and the Linnaeus Garden. Uppsala Castle,
venue of PTCOG XXXII, as well as the burial mounds of pagan kings
at Old Uppsala hold dramatic events in their past.
General information:
Scientific secretaries
Erik Blomquist MD, PhD, Assoc.Prof Erik Grusell PhD
Dept. of Oncology
Dept. of Hospital Physics
Uppsala
University
Akademiska sjukhuset
SE-751 85 Uppsala,
Sweden
Telefax: +46-(0)18-50
87 24
E-mail: erik.blomquist@onkologi.uas.lul.se
Erik.Grusell@asf.uas.lul.se
Presentations
and Posters: Please send the title of your presentation to one
of the scientific secretaries before the end of March. All talks
will be a maximum of 12 minutes including time for discussion.
If the session is full, speakers will be informed and asked to
consider a poster presentation. The maximum size for a poster
is 1.0 x 1.8 meters. Presenters are encouraged to send an abstract
of their presentation to both the conference organizers and Janet
Sisterson (jsisterson@partners.org).
The abstracts will be published with the next issue of Particles
in July 2000. Abstracts should be no more than one half page in
length.
Registration:
Please use the enclosed Registration Forms to register for the
congress and the social program, and for hotel reservations. Before
March 1 2000 the fee is SEK 1800; after March 1, SEK 2000. No
personal cheques accepted; methods of payment are given on the
registration form. Registration fees will be refunded (less SEK
500) for cancellations made before March 31 2000.
Currency The
official congress currency is SEK, Swedish Kronor - the exchange
rate as of December 14, 1999 was: SEK 100 = USD 1166; SEK 100
= EURO 1161
Special requirements:
Anyone requiring special arrangements in order to fully participate
in the congress should enclose a written description of the needs
together with the completed registration form.
Accommodation:
Uppsala Turist & Kongress AB (UTKAB) has made block-bookings
at hotels of different categories in Uppsala. (Please see hotel-listing
below) The congress venue, Uppsala castle, is within walking distance
of all the hotels. Since only a limited number of hotel rooms
have been reserved in each category, rooms will be distributed
on a first-come first-served basis. Please mark your 1st, 2nd
and 3rd choice. If the category you wish to book is complete,
a room of your next preference will be booked.
Please note that
all changes concerning accommodation must be made through Uppsala
Turist & Kongress, "XXXII PTCOG", Fyristorg 8, 753
10 UPPSALA, Sweden. Fax no.+46-18-69 24 77, e-mail: kongress@utkab.se
Radisson SAS
Hotel Gillet: located downtown Uppsala. www.radisson.com
Single room:
SEK 1.390/700* Double room: SEK 1.1650/900*
First Hotel Linné:
located by the Linneaus Garden. www.firsthotels.com
Single room:
SEK 1.148/748* Double room: SEK 1.398/748*
Hotel Svava:
located in the centre of Uppsala. www.hotelsvava.com
Single room:
SEK 1.195/650* Double room: SEK 1.395/790*
Grand Hotel Hoernan:
located by the Fyris River. www.eklundshof.se
Single room:
SEK 930/650* Double room: SEK 1.150/800*
Tariffs quoted
are per room per night and incl. sheets, breakfast and VAT, if
not otherwise specified. *Prices given are weekend rates and will
be applied only Friday and Saturday night! Prices are subject
to adjustments. All hotels offer private bath/shower/WC, telephone,
radio and TV.
Payment for accommodation
should be made directly to the hotel when checking out. Cash and
credit cards are accepted. Hotel check-in time is 15:00 or later.
If arriving after 18:00, please notify the hotel. Check-out time
is 12:00. If you arrive early in the morning it is possible that
your room will not be ready for immediate occupation on your arrival.
Should you feel it necessary, you can ensure immediate availability
by paying an extra day's tariff thus booking your room for the
night before your arrival. Please advise the congress secretariat
if you wish to take this precaution. Cancellation of your reservation
must be made one week in advance to Uppsala Turist & Kongress
or you will be charged for the first night.
Confirmation
of registration and hotel reservation: Will be sent out in March
(week no. 12) 2000.
Congress secretary:Congress
Bureau Telephone: +46-(0)18-27 48 07
"XXXII PTCOG"
Telefax: +46-(0)18-69 24 77
Uppsala Turist
& Kongress AB, E-mail: kongress@utkab.se
Fyris torg 8
SE-753 10 Uppsala,
Sweden.
Congress website:
Congress program in detail, hotel and travel information, guided
tours, sponsors and more will currently be added at http://www.uas.se/fakta/ext/medkurs.htm
Guided tour:
On April 18, 16.30-18.00 there will be a guided city walk in Uppsala
for participants and accompanying persons. Meeting point Uppsala
Castle. During this walk through some of the old parts of the
town we will visit historical buildings such as Uppsala Cathedral,
Gustavianum (with the University Museum) and the University Main
Building. SEK 65/person. Min. 25 people.
Exhibitions:
Scientific posters, commercial exhibits of industrial hardware
and software. Details on the web site.
Preliminary Program
16 Sunday Workshop:
Monte Carlo Techniques in Dose-planning
Moderator: Anders
Ahnesjö
Morning
Afternoon
17 Monday Radiobiology
and Benign targets
Dose-planning
(Glimelius)
Monday Evening:
Tour of The Svedberg Laboratory and Welcome buffet
18 Tuesday Steering
Committee Breakfast
Gantry Design
and dosimetry "Pediatric Protons" (Hug)
PTCOG Business
Meeting
Tuesday Evening:
Cultural tour and Conference dinner
19 Wednesday
General Clinic General Physics
Links to more
information about Sweden: Please visit the following Internet
sites:
Time: Sweden
is 1 hour ahead of Greenwich Mean Time (GMT).
Tourist Information:
Tourist Information, Fyris torg 8, SE-753 10 Uppsala, Sweden.
Telephone: +46-(0)18-27
48 00
Telefax: +46-(0)18-13 28 95
Website: www.res.till.uppland.nu;
this website includes a map of Uppsala
Travel to and
from Sweden and Uppsala: Arlanda International Airport is served
by more than 700 flights daily to and from more than 100 cities
in 50 countries. It is located approximately 35 kilometres south
of the center of Uppsala. During peak hours the airport coach,
#801 (www.upplandslokaltrafik.se)
leaves 2-4 times per hour to and from Uppsala. The transfer takes
about 45 minutes and costs SEK 75 (December 1999). There are also
several taxi companies operating from the airport. If you intend
to take a taxi, we recommend you to always agree a fare in advance.
Sweden also has a comprehensive railway system including high-speed
trains to all the major Swedish cities as well as to destinations
abroad. Furthermore, there are daily ferries to and from Finland
and Estonia.
Weather: The
climate in April can be quite changeable with nice and sunny spring
weather but also some rain. Average temperature ranges from approx.
10-15 C. As Uppsala Castle is a medieval building, we recommend
that you bring a sweater, should you find it chilly.
First Announcement: PTCOG XXXIII
25-27
September 2000
Berlin,
Germany
Organisation:
Hahn-Meitner Institut Berlin
Glienicker Str.
100
D-14109 Berlin,
Germany
Contact: Mrs.
Gisela Liar de Martin, Mrs. Viola Lange
Tel: +49 30 8062
2415
Fax: +49 30 8062
2097
e-mail: ptcog@hmi.de
(available from January 2000)
Date: 25-27 September
2000
Venue: Hotel
Steglitz International, Berlin
Latest Information:
http://www.hmi.de/events
The PTCOG XXXIII
will be held in conjunction with the European Cyclotron Progress
Meeting (ECPM XXXII from September 21-23, location: Hotel Steglitz
International).
The ECPM is devoted
to cyclotrons and their applications, and it will have an informal
character. Although the meeting will include review presentations
and descriptions of existing machines and equipment, its participants
should focus on novel solutions, new ideas and unsolved problems.
A first circular
for both meetings will be sent out in February 2000.
19th International Conference on Atomic Collisions
in Solids
29
July - 3 August 2001
Paris,
France
ICACS is a biannual
meeting, which deals with physical and chemical phenomena induced
by the interaction of low and high energy beams of charged or
neutral particles with matter: solids, liquids and biomaterials.
The most recent meetings have been held in Odense (Denmark, 1999)
and Beijing (China, 1997). The objectives of the Paris ICACS-19
are to assess the state of the art in the current understanding
of a variety of phenomena such as radiation damage, electron emission,
energy losses of ions, etc. While the programme will focus mainly
on the interaction of atomic, molecular and cluster projectiles,
related processes induced by electron, positron and photon beams,
will also be considered. Pertinent materials are various solids,
polymers, bio-materials and liquids. New developments in experimental
techniques may be presented. The emphasis of the meeting is on
fundamental processes, but applications in physics, chemistry,
biology and medicine will be considered. Thus use of ion beams
in cancer treatment and inactivation and mutation effects induced
by hydrogen and heavy ion beams in cells may be considered. This
rather wide programme will be of interest to the members of the
PTCOG community interested in various fundamental aspects of primary
and secondary effects of ion beams over a very wide range of energies
extending through and beyond the Bragg peak region. The programme
will consist of oral and poster presentations and sufficient time
for informal discussions will be allocated.
Interested persons
should pre-register at the ICACS website in order to receive further
information.
Contact : Vladimir
A.Esaulov, Chairman
Laboratoire des
Collisions Atomiques et Moleculaires
bat.351, Universite
de Paris Sud
91405 Orsay Cedex
France
phone : (33)1
69 15 76 80 fax : (33) 169 15 76 71
e-mail : icacs19@veof1.lcam.u-psud.fr
http://veof1.lcam.u-psud.fr/idc/icacs19.html
PTCOG Information/News/Reports:
The following
reports and articles were received by January 2000.
Tumortherapy
at GSI, Darmstadt, Germany: A status report
In December 1997,
the first two patients were treated at GSI with a carbon-ion beam.
Following these pilot irradiation, a clinical study started in
August 1998. The aim of this clinical study is to demonstrate
the superiority compared to conventional photon irradiation of
ion-beam therapy for selected indications.
Beams of heavy-charged
particles, such as carbon ions, produced a significantly more
favourable dose distribution, allowing an increase in tumour dose
while sparing healthy tissue. In addition, ions have a higher
biological effectiveness in destroying the tumour. For these reasons
ion beam therapy is recognised as particular appropriate for the
treatment of inoperable tumours in the vicinity of high-risk organs
like the brainstem as well as of photon irradiation-resistant
tumours. In the framework of the clinical study, 46 patients have
been treated so far. The eligible indications comprise: chordoma
and chondrosarcoma of the scull base, adenoidcystic carcinoma,
anaplastic and malignant meningeoma, and malignant schwannoma.
23 out of 46
patients were treated solely with heavy ions during 20 consecutive
days. The other patients received a stereotactic photon irradiation
treatment at the University Hospital of Heidelberg and the German
Cancer Research Centre (DKFZ) in Heidelberg, respectively. The
photon therapy was then complemented by a boost-irradiation with
five to six carbon ion fractions at GSI.
All 46 patients
could be treated according to plan without any severe complications.
Ever since they undergo regular follow-ups at the University Hospital
Heidelberg and the DKFZ in order to monitor the outcome of the
treatment and possible side effects caused by the irradiation.
So swelling of the mucous membrane occurred in a few cases. However,
these cases were in accordance with expectations from radiobiological
estimates and could be treated successfully, if necessary at all.
For 42 of the
46 patients treated so far, the course of disease is rather favourable
with no indication of a recurrence of the tumour within the area
irradiated with heavy ions. For the other four patients, complications
occurred that were, however, not connected to a recurrence of
the primary tumour. One patient passed away, but again this was
not due to the primary tumour that had even shown a strong reduction
after the treatment.
Despite the very
promising results obtained so far, it is still too early to draw
final conclusions on the clinical significance of ion-beam therapy.
This will require considerably higher patient numbers and much
longer follow-up periods of the patients treated. The clinical
studies will, therefore, be continued during the next years. In
addition, other indications, e.g. tumours in the vicinity of the
spinal chord or in the abdominal region, shall be included into
the study.
Because of the
positive results of this pilot project at GSI, the plans for a
realisation of a dedicated proton/ion center at the Radiological
Clinic in Heidelberg make good progress. The plans to construct
this center were approved by the Heidelberg University as well
as by the University Hospital. The scientific advisory committee
of the federal government (Wissenschaftlicher Rat) gave a positive
vote for the allocation of DEM 2 mio for a detailed planning that
will be performed within this year by the construction department
of the Heidelberg University and the accelerator division of GSI.
In fall 2000 these detailed plans will allow a rigorous cost estimate
as basis for the financing
In addition,
DEM 8.75 mio were allocated by the Helmholtz-Society in order
to develop a multifield irradiation facility for ion beams. With
this support the construction period could start by the end of
this year and first patient treatments at Heidelberg are expected
to begin five years later. Chairman of the project is Dr. Dr.
J. Debus at the DKFZ in Heidelberg.
The German Helmholtz-Society
(HGF) has given the Erwin-Schrödinger award for the development
of the heavy-ion tumortherapy to Gerhard Kraft (GSI Darmstadt),
Wolfgang Enghardt (FZR Rossendorf) and Jürgen Debus (Radiology
and DKFZ Heidelberg). The Roentgen award of the University of
Giessen was given to Michael Scholz (GSI Darmstadt) for the development
of the local effect model that calculates RBE on the basis of
X-ray data.
The new Christoph
Schmelzer award for the best PhD thesis concerning heavy-ion tumortherapy
was splitted between Catherina Brusasco from INFN Turino and Kathrin
Lauckner from FZR Dresden.
G. Kraft, GSI,
Planckstrasse 1, Darmstadt, D 64291, Germany.
FDA
approval and Medicare coverage and payment issues in proton beam
therapy:
FDA Approval:
The FDA approves medical devices for "marketing". There
are three alternative routes to obtain FDA approval to market
medical devices. The pre-market approval application ("PMA")
process involves a full-scale review of a devices safety
and efficacy by the FDA. The second route to market is a rarely
used one known as the "custom device exemption". It
is intended for devices used by a single practitioner (such as
a custom surgical device) and is not applicable to proton beam
therapy. The third route to market is referred to as "substantial
equivalency" or the 510(k) process - a reference to the relevant
section of the Medical Device Amendments.
In 1987, Loma
Linda University Medical Center ("LLUMC") acting as
the manufacturer of its proton beam therapy system submitted a
510(k) pre-market notification for its proton beam therapy system.
Massachusetts General Hospital ("MGH") is developing
its Northeast Proton Therapy Center ("NPTC"). As the
manufacturer of their system, they submitted a 510(k) pre-market
notification to the FDA in 1998. Lastly, Proton Therapy Corporation
of America ("PTCA"), a subsidiary of Tenet HealthSystem,
has contracted with Ion Beam Associates ("IBA") of Belgium
to manufacture proton beam therapy systems for facilities PTCA
is developing across the country. IBA also submitted its pre-market
notification to the FDA in 1998.
Medicare Coverage:
As the largest payor for health care services in the United States,
the Medicare program is the "gold standard" for issues
related to coverage and payment by payors of all types.
To understand
the impact of the Medicare program on proton beam therapy, it
is important to distinguish between coverage and payment. Coverage
is the process by which the Medicare program determines that a
service is "necessary and reasonable". Interestingly,
coverage does not necessarily guarantee payment although payment
cannot be made to a provider (with the exception of a few circumstances)
unless it is a covered service. As such, approval by the Medicare
program that a service is "covered" is a necessary precursor
to payment.
Coverage decisions
by the Medicare program can be made at one of two levels
nationally or locally. Until recently, there was no formal process
for making national coverage decisions. However, in April of this
year the Health Care Financing Administration ("HCFA")
released details on its national coverage process which will "streamline
our decision making process and . . . increase the opportunities
for public participation in making national coverage decisions."
This national coverage process involves a variety of steps and
involves several recently appointed (or to be appointed) advisory
panels.
The alternative
approach for obtaining Medicare coverage is a decision by a local
Medicare contractor, -a local or regional entity contracted by
the Medicare program to administer benefits in each geographic
region.
Under the provisions
of Medicare regulations, the various Medicare contractors are
encouraged to make coverage decisions on behalf of the Medicare
program particularly where a service such as proton beam
therapy is not widely available throughout the nation.
Local Medicare
coverage decisions are made via a process which is not as "rigorous"
as that described in the new Medicare national coverage process.
In general, although subject to wide variations, coverage decisions
made by contractors are made by the Carrier Medical Director ("CMD")
and his/her staff with the input and advice of a Carrier Advisory
Committee ("CAC"). The latter is an advisory group appointed
by each carrier consisting of representatives of medical specialties,
associations, other insurers, consumers, regulators, etc. Depending
on the specific Medicare contractor, this can be a fairly rigorous
process or a very informal one.
Once proposed
coverage decisions are made by a local carrier, they are provided
for comments to representatives of relevant medical specialties
and others who offer their advice to the Carrier Medical Director.
They are then published in the Carriers local medical bulletin
at which point they are open for comment by providers and others.
There is also
an informal Carrier Medical Director working group that facilitates
the interchange of information among the various Carrier Medical
Directors.
Medicare
Fee Setting: Once coverage for a new procedure is approved
fee setting by Medicare takes place. This can occur in one of
several ways depending on how coverage for the new procedure was
approved.
As the new Medicare
national coverage process has not been in place for very long,
it is not yet clear how HCFA will set fees for new procedures
for which coverage was approved through this national process.
We anticipate that such fees will be set by HCFA with the "advice
and counsel" of relevant professional organizations.
When coverage
is approved at the local contractor level, fees are typically
set and negotiated directly with that fiscal intermediary or carrier
based on a number of factors including costs, Medicare fees for
comparable procedures (should they exist) and considerations of
cost effectiveness.
CPT Coding: In
general, an appropriate CPT code is necessary to facilitate the
Medicare program (as well as other insurers) paying for services
(although it is possible to be paid by the Medicare program using
either unlisted procedure codes or "local codes" are
established by local contractors to pay for services when no code
has been established and published in the American Medical Associations
CPT Manual).
As the result
of efforts initiated by Massachusetts General Hospital with the
support of LLUMC and PTCA, the AMAs Committee on Nomenclature
approved two new CPT codes for inclusion in the 1999 CPT manual
as follows:
|
77380
|
Proton
beam delivery to a single treatment area, single port, custom
block, with or without compensation, with treatment set-up
and verification images.
|
|
77381
|
Proton
beam treatment to one or two treatment areas, two or more
ports, two or more custom blocks, and two or more compensators,
with treatment set-up and verification images.
|
In
response to additional efforts involving MGH, LLUMC, PTCA and
Indiana University, the AMA recently approved modifications to
these codes as well as several additional codes for the year 2001
CPT manual. These modified and new codes will be as follows:
Definitions
- Simple proton
treatment delivery to a single treatment area utilizing a single
non-tangential/oblique port, custom with compensation (7752X1),
and without compensation (77520).
- Intermediate
proton treatment delivery to one or more treatment areas utilizing
two or more ports or one or more tangential/oblique ports, with
custom blocks and compensators.
- Complex proton
treatment delivery to one or more treatment areas utilizing
two or more ports per treatment area with matching or patching
fields and/or multiple isocenters, with custom blocks and compensators.
- 77520 Proton
treatment delivery; simple, without compensation,
- 7752X1 simple,
with compensation
- 77523 intermediate
- 7752X2 complex
Conclusion:
Organizations considering the development of proton beam therapy
facilities are advised to clearly and fully analyze the alternatives
available to them with respect to FDA approval as well as understand
their alternatives for obtaining Medicare coverage and the setting
of fees. In light of the high capital costs and requisite investment
required to develop a facility for the routine clinical provision
of proton beam therapy such a thorough analysis and evaluation
of alternatives to obtain Medicare coverage and payment at an
acceptable level must be a key part of the early planning stages
of any new proton beam therapy facility. Alan E. Morrison, Managing
Director and Kristen Burks Clark, Managing Associate, ZA Consulting,
LLC, 101 West Avenue; Suite 300; Jenkintown, PA 19046; Telephone
(215) 517-4900; Fax (215) 572-5970; amorrison@zaconsulting.com;
kclark@zaconsulting.com.
TREATMENT
PLANNING SYSTEMS FOR PROTON THERAPY
January
2000
The following
Table was presented in October 1999 by Skip Rosenthal, MGH at
the Workshop on Treatment Planning Systems, PTCOG XXXI. Information
was provided by: S. Rosenthal, A. Mazal, M. Collier, T. Lomax,
S. Nill, and D. Miller. This Table is a new feature of Particles,
and will be updated each issue. Please send corrections/additions
to Janet Sisterson.
|
Year
|
Created
By
|
System
Name
|
Status
|
|
|
|
|
|
1979-93
|
LBL
|
LBL system
|
Not Available
|
1980
|
MGH
|
Rx
|
Distributor
MGH
|
1980
|
MGH
|
EYEPLAN
|
Distributor
MGH EYES only
|
1990-96
|
MGH/Seimens
|
V-Treat(AXIOM)
|
Not Available
|
198?,1991
|
PSI
|
PSI system/Pion
|
Distributor
PSI
|
1995
|
DKFZ/Royal
Marsden
|
Voxelplan/Proxelplan
|
Adapted
by GSI, NAC, DKFZ
|
1996
|
Radionics/MGH/HCL
|
P-Knife
|
Not Available
|
1997
|
LLUMC/PerMedics
|
OptiRad
|
Commercial
Pending FDA
|
1998
|
Tsukuba
|
Hitachi
system
|
In-house
system
|
1998
|
DKFZ
|
OCTOPUS
|
Used in
Berlin EYES only
|
1994
|
Orsay/Curie
|
ISIS
|
Distribution
?
|
1998
|
CMS/MGH
|
FOCUS
|
Commercial
Release 1999
|
1998
|
DKFZ
|
KonRad
Plus Protons
|
Research
Only
|
199?
|
Uppsala/KVI
|
Helax (+
protons)
|
Distribution
?
|
|
|
RenderPlan
|
|
?
|
|
|
Adac
|
|
?
|
|
|
Michigan
|
|
?
|
|
|
Varian
|
|
?
|
Proposed NEW FACILITIES for PROTON
& ION BEAM THERAPY - January 2000
|
INSTITUTION
|
PLACE
|
TYPE
|
1ST
RX?
|
COMMENTS
|
|
INFN-LNS,
Catania
|
Italy
|
p
|
2000
|
70 MeV;
1 room, fixed horiz. beam
|
|
NPTC
(Harvard)
|
MA USA
|
p
|
2000
|
at MGH;
230 MeV cyclotron; 2 gantries + 2 horiz
|
|
Hyogo
|
Japan
|
p,
ion
|
2001
|
2 gantries;
2 horiz; 1 vert; 1 45 deg;under construction
|
|
NAC,
Faure
|
South
Africa
|
p
|
2001
|
new treatment
room with beam line 30o off vertical.
|
|
Tsukuba
|
Japan
|
p
|
2001
|
270 MeV;2
gantries;2 fixed (research);under construction
|
|
CGMH,
Northern Taiwan
|
Taiwan
|
p
|
2001?
|
250MeV
synchrotron/230MeV cyclotron;3 gantry,1 fixed
|
|
Wakasa
Bay
|
Japan
|
|
2002
|
multipurpose
accelerator; building completed mid 1998
|
|
Bratislava
|
Slovakia
|
p,
ion
|
2003
|
72 MeV
cyclotron; p; ions; +BNCT, isot prod.
|
|
IMP,
Lanzhou
|
PR China
|
C-Ar
ion
|
2003
|
C-ion
from 100MeV/u at HIRFL expand to 900 MeV/u at CSR;clin.
treat;biol. research;no gantry;shifted patients
|
|
Shizuoka
Cancer Center
|
Japan
|
|
2002?
|
synchrotron
230? MeV; 2 gantries; 1 horiz; funded.
|
|
Erlangen
|
Germany
|
p
|
2002?
|
4 treatment
rooms, some with gantries.
|
|
CNAO,
Milan & Pavia
|
Italy
|
p,
ion
|
2004?
|
synchrotron;
2 gantry;1 fixed beam rooms;1 exp. room
|
|
Heidelberg
|
Germany
|
p,
ion
|
2005?
|
|
|
AUSTRON
|
Austria
|
p,
ion
|
?
|
2p gantry;1
ion gantry;1 fixed p;1 fixed ion;1 exp room
|
|
Beijing
|
China
|
p
|
?
|
250 MeV
synchrotron.
|
|
Central
Italy
|
Italy
|
p
|
?
|
cyclotron;
1 gantry; 1 fixed
|
|
Clatterbridge
|
England
|
p
|
?
|
upgrade
using booster linear accelerator to 200 MeV?
|
|
TOP project
ISS Rome
|
Italy
|
p
|
?
|
70 MeV
linac; expand to 200 MeV?
|
|
3 projects
in Moscow
|
Russia
|
p
|
?
|
including
320 MeV; compact, probably no gantry
|
|
Krakow
|
Poland
|
p
|
?
|
60 MeV
proton beam.
|
|
Proton
Development N.A. Inc.
|
IL USA
|
p
|
?
|
300 MeV
protons; therapy & lithography
|
|
PTCA,
Tenet HealthSystem
|
USA
|
p
|
?
|
Several
systems throughout the USA
|
WORLD WIDE CHARGED PARTICLE PATIENT TOTALS
January 2000
|