|
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fee for PTCOG meetings would be used to help produce both
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Laboratory”. We thank Steven Goetsch Ph.D. of the San
Diego Gamma Knife Center for his generous contribution which
we have used to cover some of the costs of producing this
issue of Particles.
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| ARTICLES
FOR PARTICLES 19 |
The deadline
for news for Particles 19, the January 1997 issue, is November
30 1996. I will send reminders by fax or e-mail.
Address all
correspondence for the newsletter
to:
Janet Sisterson Ph. D.
Harvard Cyclotron Laboratory
Cambridge, MA 02138
Telephone: (617) 495-2885
Fax: (617) 495–8054
44 Oxford Street
E-mail: sisterson@huhepl.harvard,edu
Articles for the
newsletter can be short but should NOT exceed two pages in length.
I DO need a good clean copy of your article and figures as I am
using a scanner to get everything into the computer. If you FAX
me an article, please send a good copy by mail. PLEASE, if you
can send me your articles by computer; much simpler for me.
| RESULTS
OF THE ELECTION OF THE PTCOG STEERING COMMITTEE |
The results of
the election of the Steering Committee of PTCOG were announced
at the Detroit PTCOG meeting. The following members were elected
to the Steering Committee :
USA Europe Russia Japan South Africa
J. Castro U. Amaldi V.Khoroshkov K. Kawachi D. Jones
W. Chu H. Blattmann H. Tsujii
M. Goitein J.-L. Habrand
D. Miller G. Munkel
J. Sisterson E. Pedroni
James Slater A. Wambersie
A. Smith
L. Verhey
| RESULTS
OF THE ELECTION OF THE PTCOG CHAIRMAN AND SECRETARY |
The new Chairman
and Secretary of PTCOG elected by the Steering Committee are:
If you have
questions about PTCOG, please contact the secretary of PTCOG
by one the means listed previously in this newsletter.
If you have questions
about PTCOG, please contact the secretary of PTCOG:
Janet Sisterson,
Harvard University
44 Oxford Street
Cambridge, MA 02138
Telephone: (617) 495-2885
Fax: (617) 495–8054
E-mail: jsisterson@partners.org
The times and
locations of the next PTCOG meetings are as follows:-
PTCOG XXV PSI, SwitzerlandCERN, Switzerland September 9-10 1996September 12-13 1996
PTCOG XXVI Boston, Massachusetts USA Spring 1997, possibly April 30 - May 2
PTCOG XXVII Chiba, Japan Fall 1997
PTCOG XXVIII Loma Linda, CA USA Spring 1998
PTCOG XXIX Europe Fall 1998
| Abstracts
for PTCOG XXV at PSI |
Authors are encouraged
to submit an abstract of their talk, which will be published with
the January 1997 issue of Particles.
Abstracts
will be collected at the meeting or they can be sent directly
to Janet Sisterson by one of the methods listed above in “articles
for Particles”. THE VERY BEST WAY is by e-mail.
See details
in the next section.
The ideal
space allocated for each abstract is ONE HALF page; PLEASE try
and keep to this length. DO NOT EXCEED one page. Please do not
use a small typeface. Each abstract must have a title and a
list of authors with addresses; graphs and line drawings are
welcome.
Second
International Symposium on Hadron Therapy
September 9 - 13, 1996
at PSI and CERN.
|
OUTLINE OF
THE PRELIMINARY PROGRAM AT PSI
Monday, September
9th
Isocentric
Beam Delivery Systems (excluding details of scanning);
Safety, Control and Dose Monitoring Systems for Scanned Beams;
Proffered Papers Physics;
(Session with invited speakers and audience discussion) Patenting
of New Technologies; Tour of the Facility in parallel with:
Workshop for centers actively involved in the comparative
treatment planning of the nasopharynx case;
Tuesday,
September 10th
Proton Irradiation
of Ocular Lesions - Clinic, Physics and Biology;
Clinical Trials with Protons - Trial Design, PROG Summary;
PTCOG Business Meeting;
Clinical Trials contd. - Lessons from EORTC, Programs of the
Proton Users Group - PUG; Proffered Papers: Experimental Tumor
Therapy and Radiobiology;
Tour of the Facility and the Social Event;
Wednesday,
September 11th
Comparative
Treatment Planning (Report on the Monday-workshop and with
discussion); Poster Presentation;
Proffered Papers - Clinical;
A session programmed by EORTC;
OUTLINE
OF THE PRELIMINARY PROGRAM AT CERN
Thursday,
September 12
Welcome addresses
Invited talks:
Status
and future directions of tumor therapy;
Clinical programs: a review of past and existing hadrontherapy
protocols, their results and future perspectives;
Impact of modern radiobiology on clinical radiotherapy;
What radiobiology should be done in a hadron therapy center?;
The role of animals in cancer research;
Boron neutron capture therapy: a review of the Zurich meeting;
Technology of hadron therapy: a review of existing technologies,
their plusses and minuses Round table: Discussion of the
latter topic
Inauguration of the exhibition Hadrons for Health
Conference dinner
Friday,
September 13
Invited talks:
Advances
in computing in the short and long term;
The invention and developments of WWW;
Medical applications of networks;
Clinical trials and ethical issues in cancer research;
Advances in large and precise mechanical structures (CERN);
Robotics;
Recent developments in radiation detectors and beam position
monitors;
Proffered papers: patient alignment;
Poster session on hadron therapy;
Invited
talks:
Abstracts:
Deadline
for the announcement of presentations is August 10, 1996.
The abstracts of the presentations at the PSI part of the conference
and of the posters will be published - as usual one half page
- in PARTICLES, the PTCOG newsletter, which appears twice yearly
and is edited by Janet Sisterson from the Harvard Cyclotron
Laboratory. The most convenient way to submit these abstracts
is e-mail to Janet Sisterson and PSI. Status reports will be
presented on posters only. Should the amount of announced oral
contributions exceed the time frame of the session, the scientific
committee will decide upon oral presentation or poster presentation
and inform the author(s) by August 23, 1996. All invited papers
for the CERN part of the symposium will be published in a volume,
as announced in the first bulletin. Authors of short presentations
and posters (PSI part) may also submit an extended text for
the volume.
Hotels:
For the PSI
part of the meeting, blocks of rooms have been reserved in several
hotels in Brugg (closest to PSI), Baden (resort town) and Regensdorf,
with special rates for participants. September is high season
in this lovely area with thermal spas, you should bring swimsuits.
For the
CERN part of the meeting, blocks of rooms have been reserved
in two Movenpick hotels and in the CERN foyer.
Please make
your reservation with the hotels directly, mentioning the
block name HADRON 96. Hotel rooms will be held until August
14 at the special rates. Book early! There are only a limited
number of rooms and it is high season.
Hotels:
PSI part of the Symposium
A block of
rooms has been reserved for the SECOND INTERNATIONAL SYMPOSIUM
ON HADRONTHERAPY at the Movenpick Hotel in Regensdorf and several
hotels in Baden and Brugg (see general information). Transportation
between the hotels and PSI, Villigen, is provided.
The rooms
are being held at a special rate. Your reservation must be
received by the hotels no later than August 14th, 1996 to
qualify for the special rate. The reduced rates are limited
by room availability, and therefore it is advisable to make
your reservations as soon as possible. Conference participants
should contact the hotels directly to make their reservations
by mentioning the blockname Hadron 96 !
Movenpick
Hotel available during your stay at PSI, Villigen:
Movenpick
Hotel Zurich-Regensdorf
Zentrum
8105 Regensdorf
Tel. ++41/(0)1 871 51 11
Fax ++41(0)1 871 50 11
Room rates: single and double 165 CHF, breakfast 16 CHF
Other hotels
provided during your stay at PSI, Villigen: Breakfast is included
in all these hotels
Hotel Du Parc Hotel Linde
Romerstrasse 24, 5400 Baden Mellingerstrasse 22, 5400 Baden
Tel. ++41 (0)56 221 03 11 Tel. ++41 (0)56 222 53 85
Fax ++41 (0)56 222 07 93 Fax ++41 (0)56 222 07 70
Single: 195 CHF Double: 280 CHF Single: 148 CHF Double: 195 CHF
Hotel Schweizerhof Hotel Kappelerhof
Kurplatz 3, 5400 Baden Bruggerstrasse 142, 5400 Baden
Tel. ++41 (0)56 221 03 25 Tel. ++41 (0)56 222 38 34
Fax ++41 (0)56 221 58 04 Fax ++41 (0)56 222 55 32
Single: 115 CHF Double: 190 CHF Single: 125 CHF
rate held until July 31st only
Hotel Verenahof Hotel Hirschen
Kurplatz 1, 5400 Baden Badstrasse 22, 5400 Baden
Tel. ++41 (0)56 203 93 93 Tel. ++41 (0)56 222 69 66
Fax ++41 (0)56 203 93 94 Fax: -
Single: 140 CHF Double: 115 CHF Room with basen: 46 CHF
Hotel Terminus
Bahnhofplatz 1, 5200 Brugg
Tel. ++41 (0)56 441 18 21
Fax ++41 (0)56 441 82 20
Single: 95 CHF Double: 155 CHF
Movenpick Hotels:
CERN part of the Symposium
A block of
rooms has been reserved for the SECOND INTERNATIONAL SYMPOSIUM
ON HADRON THERAPY at the Movenpick Hotels in Geneva. Transportation
between the hotels and CERN is provided.
The rooms
are being held at a special rate. Your reservation must be
received by the hotel no later than August 14th, 1996 to qualify
for the special rate. The reduced rate is limited by room
availability and, therefore, it is advisable to make your
reservations as soon as possible. Conference participants
should contact the hotels directly to make their reservations
by mentioning the blockname Hadron 96 ! In both Movenpick
Hotels cancellation of the reservation without penalty must
be made at the latest 48 hours before the expected arrival.
Hotel Movenpick Cadett Hotel Movenpick Radisson
Mategnin, 21, Route Pre-Bois 20
1217 Meyrin (Geneve) 1215 Geneve 15
Tel. ++41/(0)22 989 90 00 Tel. ++41/(0)22 798 75 75
Fax ++41/(0)22 989 99 99 Fax ++41/(0)22 791 02 84
single & double 115 CHF, single and double 170 CHF,
breakfast 19 CHF breakfast 24 CHF
Another
possibility to stay at CERN in Geneva
CERN Foyer
1221 Geneve 23 Tel. ++41(0)22 767 41 55 Fax ++41(0)22 767
38 00 Please mention here the blockname AMALDI! Reservations
should be made at the earliest, as it is holiday period. Room
rate: 51 CHF
Transportation:
To hotels
(PSI): The Hotel Terminus in Brugg is situated right opposite
the Brugg train station. The enclosed brochure “How to
get to the Paul Scherrer Institute” describes the way
to the institute by airplane, train and car - and includes
information on getting to Brugg. If you stay in one of the
hotels in Baden, you take the same trains from the airport
(or from other places via Zurich) as for getting to Brugg;
just get off the train one stop earlier. There is a shuttle
service between the airport Zurich - Kloten and the Movenpick
Hotel in Regensdorf.
From hotels
to PSI: There will be bus transportation from all hotels to
PSI. Detailed information will be available on your arrival
at the hotel desk. In addition, for the Hotel Terminus, the
postal bus leaves from right opposite the hotel and takes
you right in front of the conference building at PSI. Time
schedules are available at the hotel desk.
To hotels
(CERN): Hotel shuttle minibuses (marked Movenpick) are available
between the Geneva - Cointrin airport and both Movenpick Hotels.
If you arrive by train, you should go to the train station
in the airport, and then use the minibuses to the hotels.
Coming by car, head for the Geneva - Cointrin airport via
the highway N1 / E4 or one of the well maintained country
roads. All Swiss maps will guide you there safely.
From hotels
to CERN: There will be bus transportation from the hotels
to CERN. By bus between PSI and CERN: Will be provided (with
an additional charge) for participants who are attending both
parts of the meeting, and companions.
Registration:
The registration
fees include coffee, lunches, transportation between hotels
and the conference places, the social event and dinner on Tuesday
evening (incl. bus) and the dinner and bus for participants
on Thursday evening. Not included in the registration fee(s)
are: the conference dinner(s) for guests, and the bus transportation
from PSI to CERN on Wednesday. If you have already registered,
and wish to bring a guest to any of the social events /conference
dinners, please let the secretariat know by August 20, 1996.
Please read the registration form and payment information carefully!
The registration fees are different for the entire Hadron Symposium
and for only one part of the meeting. If you decide to pay at
the registration desk, please bring cash or traveler cheques.
No credit cards or personal cheques can be accepted, Sorry!
Social events
and conference dinners:
On Tuesday,
a visit to the Landvogteischloss in Baden will begin the social
part of the conference at PSI. The Landvogteischloss is a local
museum for the history of the region from Roman to modern times.
After the aperitif and a short presentation (in English) about
the exposition you will have an opportunity to visit the museum.
A dinner will follow at the Movenpick Hotel in Regensdorf, with
bus transportation provided. The conference dinner during the
CERN part of the symposium will take place at the Movenpick
Hotel Cadett in Geneva - Meyrin. On Saturday morning a tour
of CERN, and of the DELPHI experiment in particular, is planned.
Participation forms will be handed out on site.
WORLD
CONGRESS ON MEDICAL PHYSICS AND BIOMEDICAL ENGINEERING
Nice, France, September 14 - 19 1997 |
From 14 - 19
September 1997, the WORLD CONGRESS ON MEDICAL PHYSICS AND BIOMEDICAL
ENGINEERING will take place in Nice on the French Riveria.
After Kyoto
(1991) and Rio (1994), it will provide an unique opportunity
for scientific exchanges and discussions on various topics of
interest for all those involved in “Particle therapy”.
- For Scientific
contacts on “protons, neutrons and heavy ions in radiotherapy”
Alejandro MAZAL
Centre de Protontherapie d’Orsay, BP. 65
91402 ORSAY CEDEX - FRANCE
Phone: + 33 1 69 29 87 00
Fax: + 33 1 69 07 55 00
| PTCOG
News: The following reports were received by July 1996.
|
Status report:
The Northeast Proton Therapy Center, at Massachusetts General
Hospital, Boston, MA USA:
The Northeast
Proton Therapy Center (NPTC) continues to be essentially on
schedule and without changes in the overall budget. Some time
was lost during the winter due to the discovery, and subsequent
extraction, of a large number of old wood piles in locations
where concrete piles were to be driven. Several large concrete
caissons were also uncovered on the construction site and
had to be removed. The building is scheduled for completion
in January, 1997 at which time we will begin the installation
of equipment. Some personnel will move into the building at
that time.
The second
isocentric gantry was procured in January of 1996. The shipping,
assembly, and installation reviews of the cyclotron, energy
selection system, beam transport system, gantries, nozzles,
and patient positioner system are scheduled for December,
1996. The cyclotron and energy selection system are scheduled
to arrive at MGH in February, 1997 while the beam transport
system will arrive March-May. The first gantry will be delivered
in April and the second will arrive in May. The NPTC control
and safety systems will be installed in the summer of 1997
and the patient positioning systems will be installed in the
Fall.
We plan
for the NPTC systems acceptance tests to be completed in February,
1998 after which the clinical commissioning of all systems
will commence. Patient treatments are scheduled to begin in
the early Fall, 1998.
Alfred
Smith, The Northeast Proton Therapy Center, Massachusetts
General Hospital, Boston, MA 02114, USA.
Clinical
Trials Update: Proton Radiation Oncology Group (PROG)
PROG’s
goal is to provide a centralized research base, not available
elsewhere, for clinical trials employing proton therapy. PROG
has been funded by the National Cancer Institute-U.S. to:
a) undertake clinical trials and other related studies to
assess the extent of the gain and the cost of that gain achieved
by use of proton beams in the treatment of the cancer patient,
b) improve the control of primary and regional malignant disease
by use of proton beam radiation therapy and to the study patterns
of failure, c) coordinate the scientific activities of group
members and committees and to foster the design and implementation
of protocols within a unified research program, and to d)
collaborate with clinical investigators on statistical and
scientific aspects of planning new studies and to prepare
interim statistical reports for each ongoing study.
Loma Linda
University Medical Center and Massachusetts General Hospital
are actively accruing patients to PROG studies. In addition,
there is committed growth in PROG membership by proton beam
therapy centers abroad. The medical directors at four foreign
proton therapy treatment centers have written to indicate
interest in participating in PROG studies; these include:
Paul Sherrer Institut, Switzerland; the National Accelerator
Centre, South Africa; Centre de Protontherapie, Orsay; and
the University of Tsukuba, Japan. This substantial increment
in the number of participants is anticipated to more than
double the current accession rate. PROG statisticians review
all study designs regardless of phase to ensure they are appropriate
to the scientific question posed. All accruing studies are
monitored on a semi-annual basis to identify and resolve any
problems. Analyses performed by the statisticians produce
results that become the basis for presentations at medical
meetings and publications in refereed journals. The statisticians
have collaborated with the investigators on the publication
of 19 manuscripts and 4 abstracts.
Current
Studies:
- PROG 85-26
Phase I/II Randomized Study of Charged Particle Radiation
in the Treatment of Chordomas of Low Grade Chondrosarcomas
of the Base of Skull or Cervical Spine (Munzenrider)opened:
2/9/87, accrual as of 6/1/96: 261
- PROG 92-13
Prospective Study of Patients with Recurrent or Incompletely
Excised Benign Intracranial Meningiomas for the Evaluation
of Treatment Results with Combined Proton & Photon Irradiation
to Doses of 55.8 or 63.0 CGE (Munzenrider) opened: 8/1/94,
accrual as of 6/1/96: 10
- PROG 92-14
Phase I/II Study Employing Proton Therapy for the Treatment
of Squamous Cell Carcinoma of the Oropharynx (Slater)opened:
10/1/93, accrual as of 6/1/96: 7
- PROG 92-15
Phase I/II Study of Hyperfractionated, Accelerated Radiation
Therapy for Advanced Paranasal Sinus Carcinoma Employing
Combined Proton and Photon Irradiation (Thornton)opened:
10/1/93, current accrual as of 6/1/96: 1
- PROG 95-09
Phase III Trial Employing Conformal Photons with Proton
Boost in Early Stage Prostate Cancer: Conventional Dose
Compared to High Dose Irradiation (Zietman) opened: 1/31/96,
current accrual as of 6/1/96: 27
Treatment
protocols will be developed for tumors in pediatric patients;
carcinomas of several head and neck sites; carcinomas of the
rectum/recto-sigmoid; sarcomas of the soft tissues of the
retroperitoneum; carcinoma of the uterine cervix; non small
cell lung cancer, carcinoma of the urinary bladder, stage
3; malignancies of the biliary duct; hepatic malignancy, and
for patients with intracranial arteriovenous malformations.
Presentations on the prostate protocol and the importance
of a centralized statistical data base will be made at the
Fall PTCOG meeting. Information regarding PROG is available
from:
Elaine
Pakuris, PROG Project Administrator, ACR, 1101 Market Street,
Philadelphia, PA 19107, 215-574-3195, FAX 215-928-0153, e-mail
epakuris@acr.org
Heavy Ion Therapy at GSI, Darmstadt, Germany:
The medical
annex has been constructed and furnished this winter. Commissioning
of the medical beam line and the new rasterscan is continued
using a prototype control system. The final system combining
the scanner control and safety inputs as for instance the fast
position sensitive counters and other safety controls is not
yet ready. This delay is mainly due to the complexity of the
safety and control system and the integration of components
that have been tested as single prototypes only.
Another
important safety equipment, the PET camera developed by the
FZR Dresden has been installed and tested with carbon beams
scanned to various 3-D volumes into plastic or gel-targets.
Figure 1 shows the results of a PET reprojection of 14 spills
produced by the irradiation with 12C ions of 108 particles
in total. From this and further experiments it is evident
that the critical spots of the treatment field can be tested
with a low intensity beam before main treatment starts.
Figure 1.
PET image of the scanned irradiation of a plastic block with
carbon ions.
Good progress
has been made also in the commissioning of the accelerator.
For raster scanning the accelerator settings have to be changed
from pulse to pulse (i.e. within 2 seconds). For the treatment
of one fraction, up to 60 different energies out of a set
of 255 virtual energies can be combined with one spot size
out of 4 between 4 and 10 in diameter and with one beam intensity
of 10 between 5 x 106 and 1 x 108 particles/sec. The energy
and intensity variation from pulse to pulse has been tested
successfully including the beam transport to the cave.
In order
to ensure a correct dose, a dosimetry comparison with Loma
Linda and Chiba has been carried out from the DKFZ group Heidelberg
and yielded satisfactory results. Large progress has been
made in treatment planning. A code, called TRIP developed
at GSI has been completed and integrated into the Voxelplan
system of DKFZ. TRIP is a biology oriented planning system
that optimizes first the physical dose distribution and uses
this distribution as input for a second, more elaborate biological
optimization procedure. In this code, the various dose distributions
originating from particles of different atomic numbers and
energies are known for each volume element. Therefore, the
local RBE values have to be calculated according to its composition
using a new model developed recently at GSI. In this way inhomogeneous
RBE distribution can be combined with the appropriate physical
dose in order to achieve the desired biological effect.
The treatment
planning system TRIP has been used for a fractionated treatment
of minipigs where three skin fields have been exposed with
graded doses of carbon ions and three with x-rays. The results
showed that the theoretical RBE values for early effects are
correct within the error of the experiment. This minipig experiment
has been performed in collaboration with the TU and FZR both
at Dresden. Another animal experiment irradiating Ehrlich
Ascites tumor cells in mice has been performed in cooperation
with the Radiological Institute of the University of Frankfurt
and is now being analyzed. This and other biology experiments
will be reported later.
On the administrative
side, the safety report and the request for approval have
been finalized and submitted to the government. There, an
expert commission has been formed that will visit GSI in June
and start its review process necessary for legal approval.
In general,
the project in presently delayed by 4 - 6 months compared
to the original plan from 1992 and the treatment of the first
patient cannot be scheduled before the end of 1996.
G. Kraft,
GSI mbH, Planckstrasse 1, D-64291 Darmstadt, Germany.
News from ITEP, Moscow, Russia:
In recent years,
two treatment rooms have been functioning at ITEP PTF (intracranial
irradiation in supine position , eye irradiation and other targets
in seated position). About 150 patients are irradiated per year.
Prostate and gynaecological irradiations have been temporarily
suspended. Within the framework of the H-minus TEST experimental
programme (acceleration of H-minus ions in ITEP synchrotron),
a new fourth channel is under construction for the external
proton beam of up to 200 MeV energy. The objective is the parameters
study of the proton beam obtained by recharge of H-minus ions,
and its suitability for modern proton dose delivery - GANTRY
and 3D scanning systems.
V. Khoroshkov,
ITEP, B. Cheremushkinskaya 25, Moscow 117259, Russia.
Proton Treatment Facility at the National Cancer Center
Hospital East, Kashiwa, Japan:
National Cancer
Center, Japan had determined to build a dedicated proton treatment
facility, and obtained the national funds in 1995. We had made
clinical and technical requirements of the equipment. Because
it was an international competitive bidding, the selection of
the vendor was carried out by the process of total evaluation
of the technical scores and the cost.
The facility
will be build at its' Kashiwa campus which is some 30 km from
its' Tokyo campus. It will be connected with the National
Cancer Center Hospital East (NCCHE) by a passage.
The Equipment:
Three vendors submitted their proposals (two for synchrotrons,
and one for cyclotron), finally, Sumitomo Heavy Industries
Ltd. (SHI) was selected as a main contractor of the equipment
in March 1996. Details of each part is now under discussion.
What we determined up to now is as follows;
Accelerator
will be a 235 MeV cyclotron. There will be three treatment
rooms, two with isocentric gantries and one with fixed horizontal
beam. Double scatterer or Wobbler scanning will be used initially
as a beam spreading system. Active scanning method will be
a future plan. Maximum diameter of the fields will be 30 cm
at the gantries and 10 cm at the horizontal beam. Patient
positioning system (couch) will rotate isocentrically, move
horizontal, lateral, vertical and also it will roll (up to
5 degrees) to adjust the patient's position. For the fixed
horizontal beam, a chair will be used. We are going to use
real time digital fluoroscopic radiography (DR) system for
verifying patient's position. Respiration gating system will
be introduced to the two gantries. A dedicated helical CT
scanner, an X-ray simulator and a MRI unit will be introduced
for treatment planning and evaluation.
The Building:
Tokyu Construction Co. was selected as a main contractor of
the building in March 1996. The building will provide approximately
4700 net square meter, and will have three floors (Figure
1. The building seen from the south-west side. Existing NCCHE
can be seen in the left side).
The ground
level will be a treatment floor, which include cyclotron,
beam transport lines, control rooms and three treatment rooms
(Figure 2). Part of the gantries extend below the floor. The
2nd. level will contain accelerator main control room and
bolus & collimator shop. The 3rd. level is a diagnosis
and planning floor. All the diagnostic and treatment planning
equipment will be introduced into the floor. Also on this
level will be consultation and education rooms, computer and
physics rooms, immobilization fabrication and storage areas,
conference rooms and staff offices.
Schedule:
A groundbreaking ceremony was held on May 14, 1996. The schedule
is very tight due to the Japanese government's policy of budget
plan. The building construction and equipment installation
will be finished in the first half of 1997. We hope the beginning
of treatment will be in the first half of 1998. This project
will be carried out in collaboration with the National Institute
of Radiological Sciences (NIRS), in Chiba.
Takashi
Ogino, M.D., Head of Div. of Radiation Oncology, The National
Cancer Center Hospital East, Kashiwa, Chiba 277, Japan.
News from Clatterbridge Centre for Oncology, UK:
In conjunction
with the Clatterbridge Cancer Research Trust, we have completed
a large series of radiobiological measurements of tumour and
endothelial cell lines. This was motivated by the possibility
of treating age-related macular degeneration with protons where
the target is neovascular tissue. A known tumour cell-line was
used as a reference to test the experimental methodology. RBE
values were derived by comparison with Co-60 irradiations performed
at the radiotherapy department. The results will be presented
at the PSI PTCOG in September by Dr C Walker. Out of several
proposed methods of boosting the existing cyclotron energy (62
MeV) by a proton linac booster, one is being pursued in collaboration
with Daresbury Synchrotron Radiation Laboratory and CERN. Some
preliminary measurements are scheduled based on initial calculations.
Andrzej Kacperek, Douglas Cyclotron Unit, Clatterbridge Centre
for Oncology Bebington, Wirral, L63 4JY, UK.
| Proposed
NEW FACILITIES for PROTON & ION BEAM THERAPY |
List dated
July 1996
INSTITUTION PLACE TYPE 1ST COMMENTS
RX?
P.S.I Switzerland p 1996 200 MeV, var. energy, gantry, dedicated line
Berlin Germany p 1997 72 MeV cyclotron; eye treatment beam line.
G.S.I Darmstadt Germany ion 1997 First Carbon beam in the medical cave 7/6/95
KVI Groningen The Netherlands p 1998 plan:- 200 MeV accel.; 2 rms; 1 gantry; 1 fix.
NPTC (Harvard) MA U.S.A. p 1998 at MGH; 235 MeV cyclotron; 2 gantries + 3 horiz.
Kashiwa Japan p 1998 235 MeV cyclotron; 2 gantries, 1 horiz. beam
NC Star NC U.S.A. p 1999? synchrotron; 70-300 MeV; 2 horiz; 1 gantry
Regensburg Germany p 1999? gantry;1 fixed beam; 1 eye beam.
Hyogo Japan ion 2000 protons & ion; 2 gantries; 1 horiz; 1 vert; 1 45 deg.
TERA Italy p, ion 2002? H- accel; 60-250 MeV p; +BNCT; isotope prod.
AUSTRON Austria ion ? protons and light ions.
Beijing China p ? 250 MeV synchrotron.
Central Italy Italy p ? cyclotron; 1 gantry; 1 fixed
Clatterbridge England p ? upgrade using booster linear accelerator.
ITEP Moscow Russia p ? 3 horiz.-1 fix beam, 2 gantry, 1 exp., H- accel.
Jülich (KFA) Germany p ? exp. beam line; plans for therapy.
Krakow Poland p ? 60 MeV proton beam.
Kyoto Japan p ? 250 MeV synchrotron; gantry; 1 fixed horiz beam.
Proton Development N.A. Inc. IL USA p ? 300 MeV protons; therapy & lithography
PROTOX England p 2001? existing RAL synchrotron; 250 MeV; 3 treat. gantry
| WORLD
WIDE CHARGED PARTICLE PATIENT TOTALS |
List
dated July 1996
WHO WHERE WHAT DATE DATE RECENT DATE
FIRST LAST PATIENT OF
RX RX TOTAL TOTAL
Berkeley 184 CA. U.S.A. p 1954 1957 30
Berkeley CA. U.S.A. He 1957 1992 2054 June-91
Uppsala Sweden p 1957 1976 73
Harvard MA. U.S.A. p 1961 6785 June-96
Dubna Russia p 1967 1974 84
Moscow Russia p 1969 2838 May-96
Los Alamos NM. U.S.A. ¹- 1974 1982 230
St. Petersburg Russia p 1975 969 Dec-95
Berkeley CA. U.S.A. heavy ion 1975 1992 433 June-91
Chiba Japan p 1979 86 June-93
TRIUMF Canada ¹- 1979 1994 367 Dec-93
PSI (SIN) Switzerland ¹- 1980 1993 503
PMRC, Tsukuba Japan p 1983 462 July-95
PSI (SIN) Switzerland p 1984 2054 Dec-95
Dubna Russia p 1987 40 June-96
Uppsala Sweden p 1989 81 Mar-96
Clatterbridge England p 1989 698 June-96
Loma Linda CA. U.S.A p 1990 2000 July-96
Louvain-la-Neuve Belgium p 1991 21 Nov-93
Nice France p 1991 636 Nov-95
Orsay France p 1991 673 Nov-95
N.A.C. South Africa p 1993 130 Mar-96
IUCF IN USA p 1993 1 Dec-94
UCSF - CNL CA U.S.A p 1994 71 May-96
HIMAC, Chiba Japan heavy ion 1994 104 April-96
TRIUMF Canada p 1995 5 Dec-95
1100 pions
2591 ions
17737 protons
TOTAL 21428 all particles
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990205 For Program Information contact: Dr
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