Griffith R. Harsh IV, M.D. He can now be found at: http://www.stanford.edu/dept/neurosurgery/index.html MD Degree: Harvard Medical School 1980 Residency: University of California San Francisco Medical Center Neurosurgery 1986 Fellowship: University of California, San Francisco Medical Center Neuro-oncology 1988 Board Certifications: Neurosurgery 1989

Selected Publications:

• Harsh GR IV, Wilson CB. Central nervous system mesenchymal chondrosarcoma. J Neurosurg 1984; 61:375-381.
• Harsh GR IV, Wilson CB. Neurogenic hypertension and microvascular cross-compression: a review of 50 cases of hemifacial spasm. Surg Forum 1984; 35:489-491.
• Harsh GR III, Harsh GR IV. Missile injury to the brain. In: Wilkins RH, Rengachary SS, eds. Neurosurgery. New York: McGraw Hill, 1984:1670-1678.
• Westphal M, Harsh GR IV, Rosenblum ML, Hammonds RG Jr. Epidermal growth factor receptors in the human glioblastoma cell line SF268 differ from those in epidermoid carcinoma cell line A431. Biochem. Biophys. Res. Commun. 1985; 132:284-289.
• Kelly WM, Harsh GR IV. CT of petrous carotid aneurysms. AJNR 1985; 6:830-832.
• Harsh GR IV, Edwards MSB, Wilson CB. Intracranial arachnoid cysts in children. J Neurosurg 1986; 64:835-842.
• Trent J, Meltzer P, Rosenblum M, Harsh G, Kinzler K, Mashal R, Feinberg A, Vogelstein B. Evidence for rearrangement, amplification, and expression of c-myc in a human glioblastoma. Proc. Natl. Acad. Sci. USA 1986; 83:470-473.
• Harsh GR, Nishimura RN, Dwyer BE, Levin VA. L-fucose labeling of brain tumors in rats. Exp. Neurol. 1986; 94:21-28.
• Harsh GR IV, Sypert GW, Weinstein PR, Ross DA, Wilson CB. Cervical spine stenosis secondary to ossification of the posterior longitudinal ligament. J Neurosurg 1987; 67:349-357.
• Harsh GR IV, Levin VA, Gutin PH, Seager M, Silver P, Wilson CB. Reoperation for recurrent glioblastoma and anaplasic astrocytoma. Neurosurgery 1987; 21:615-621.
• Starksen NF, Harsh GR IV, Gibbs VC, Williams LT. Regulated expression of the platelet-derived growth factor A chain gene in microvascular endothelial cells. J Biol Chem 1987; 262:14381-14384.
• Kavanaugh WM, Harsh GR IV, Starksen NF, Rocco CM, Williams LT. Transcriptional regulation of the A and B chain genes of platelet-derived growth factor in microvascular endothelial cells. J Biol Chem 1988; 263:8470-8472.
• Harsh GR IV. The treatment of malignant gliomas in adults: a commentary. Oncology 1988; 2:60-63.
• Harsh GR IV, Weinstein PR. Extracranial-to-intracranial bypass for nonatherosclerotic or therapeutic cerebrovascular occlusion. In: Erickson DL, ed. Revascularization for the Ischemic Brain. Mount Kisco, NY: Futura Publishing Company, 1988:235-289.
• Ciricillo SF, Harsh GR IV, Edwards MSB. Intracranial arachnoid cysts in children. Contemp Neurosurg 1989; 11:1-6.
• Harsh GR IV, Rosenblum ML, Williams LT. Oncogene-related growth factors and growth factor receptors in human malignant glioma-derived cell lines. J Neuro-Oncol 1989; 7:47-56.
• Harsh GR, Kavanaugh WM, Starksen NF, Williams LT. Cyclic AMP blocks expression of the c-sis gene in tumor cells. Oncogene Res 1989; 4:65-73.
• Harsh GR IV, Gutin PH. Brain tumors. In: Rakel RE, ed. Conn's Current Therapy. Philadelphia: WB Saunders, 1989:844-847.
• Harsh GR, Keating MT, Escobedo JA, Williams LT. Platelet-derived growth factor (PDGF) autocrine components in human tumor cell lines. J Neuro-Oncol 1990; 8:1-12.
• Bederson JB, Harsh GR IV, Walker JA, Wilson CB. Radiation-induced bilateral cystic temporal lobe necrosis: reversal of memory deficit after fenestration and internal shunting. J Neurosurg 1990; 72:503-505.
• Harsh GR IV, Wilson CB. Neuroepithelial tumors of the adult brain. In: Youmans JR, ed. Neurological Surgery. 3rd ed. Philadelphia: WB Saunders, 1990:3040-3136.
• Tien R, Harsh GR IV, Dillon WP, Wilson CB. Unilateral hydrocephalus caused by an intraventricular venous malformation obstructing the foramen of Monro. Neurosurgery 1990; 26:664-666.
• Lyons J, Landis CA, Harsh G, Vallar L, Grenwald K, Feichtinger H, Duh Q-Y, Clark OH, Kawasaki E, Bourne HR, McCormick F. Two G protein oncogenes in human endocrine tumors. Science 1990; 249:655-659.
• Landis CA, Harsh G, Lyons J, Davis RL, McCormick F, Bourne HR. Clinical characteristics of acromegalic patients whose pituitary tumors contain mutant Gs protein. J Clin Endocrinol Metab 1990; 71:1416-1420.
• Harsh GR IV, Liebel SA, Barbarao NM, Gutin PH. Brachytherapy: interstitial and intracavitary irradiation of brain tumors. In: Youmans JR, ed. Neurological Surgery. 3rd ed. Philadelphia: WB Saunders, 1990:3438-3446.
• Harsh GR IV, Wilson CB. Peritorcular ;meningiomas. In: Wilkins RH, Rengachary SS, eds. Neurosurgery Update. New York: McGraw-Hill, 1990:428-433.
• Harsh GR IV. Spine function score for assessment of arm, leg, and sphincter function. Neurosurgery 1990; 26:1087-1088 (letter).
• Mampalam TJ, Harsh GR IV, Tien RD, Dillon WP, Wilson CB. Unilateral hydrocephalus in adults. Surg Neurol 1991; 35:14-19.
• Ciricillo S, Cogen PH, Harsh GR, Edwards MSB. Intracranial arachnoid cysts in children: a comparison of the effects of fenestration and shunting. J Neurosurg 1991; 74:230-235.
• Horton JC, Harsh GR IV, Fisher JW, Hoyt WF. Von Hippel-Lindau disease and erythrocytosis: radioimmunoassay of erythropoietin in cyst fluid from a brainstem hemangioblastoma. Neurology 1991; 41:753-754.
• Harsh GR IV, Wilson CB, Hieshima GB, Dillon WP. Magnetic resonance imaging of vertebrobasilar ectasia in tic convulsif. J Neurosurg 1991; 74:999-1003.
• Harsh GR IV, Wilson CB. Meningiomas of the peritorcular region. In: Al Mefty O, ed. Meningiomas. New York: Raven Press, 1991:363-369.
• Harsh GR IV, Weinstein PR. Cervical myeloradiculopathy due to ossification of the posterior longitudinal ligament. In: Saunders, Bernini, eds. Cervical Spondylotic Myelopathy. Cambridge, MA: Blackwell Scientific, 1991.
• Harsh GR IV, Eastwood S. "Paddy" versus "patty." J Neurosurg 1991; 75:840-841.
• Harsh GR IV, Sekhar LN. The subtemporal, transcavernous, anterior transpetrous approach to the upper and middle clivus. J Neurosurg 1992; 77:709-715.
• Taylor SL, Barakos JA, Harsh GR IV, Wilson CB. Magnetic resonance imaging of tuberculum sella meningiomas: preventing preoperative misdiagnosis as pituitary macroadenomas. Neurosurgery 1992; 31:621-627.
• Duma CM, Lunsford LD, Kondziolka D, Harsh GR IV, Flickinger JC. Stereotactic radiosurgery of cavernous sinus meningiomas as an addition or alternative to microsurgery. Neurosurgery 1993; 32:699-705.
• Harsh GR IV. Neuro-Oncology: an overview. Classification, pathology and oncogenesis. In: Wilkins RH, Rengachary SS, eds. Principles of Neurosurgery. New York: Gower, 1994.
• Harsh GR IV. Surgical resection of meningioams of the torcular Herophili. In: Rengachary SS, Wilkins RH, eds. Atlas of Neurological Surgery. Baltimore: Williams and Wilkins, 1993.
• Harsh GR IV, Kim D. Brain Tumors. In: Salcman M, ed. Current Medicine: Neurosurgery, 1993.
• Flickinger JC, Kondziolka D, Lunsford LD, Coffey RJ, Goodman ML, Shaw EG, Hudgins WR, Weiner R, Harsh GR, Sneed PK, Larson DA. A multi-institutional experience with stereotactic radiosurgery for solitary brain metastasis. International Journal of Radiation Oncology, Biology, and Physics 1994; 28(4): 797-802.
• Lalwani A, Jackler R, Harsh GR IV, Butt FY. Bilateral temporal bone encephaloceles after cranial irradiation. Case report. J Neurosurg 1993; 79:596-599.
• Yu JS, Short MP, Schumacher J, Chapman PH, Harsh GR IV. Intramedullary hemorrhage in spinal cord hemangioblastoma. Report of two cases. J Neurosurg 1994; 81:937-940.
• Hochberg F, Harsh G, Nachtigall L, Katznelson L, Lessell S, Bloch K, McLoud T, de la Monte S, Nielsen GP, Richardson EP, Scully R. Clinical Pathologic Conference: Massachusetts General Hospital. New Engl J Med. In press.
• Aronen HJ, Gazit IE, Louis DN, Pardo FS, Buchbinder BR, Harsh G, Cosgrove R, Hochberg FH, Rosen B. Functional imaging of gliomas using susceptibility contrast CBV mapping: A comparison with tumor grade and histological features. Radiology 1994; 191:41-51.
• Rosenberg W, Harsh GR IV. Penetrating Cerebral Trauma. In: Loftus C, ed. Neurosurgical Emergencies, Vol. 1. Park Ridge: AANS Publications Committee, 1994.
• Halliday AS, Harsh GR IV. Meningiomas: Clinical Features. In: Tindall G, ed. Contemporary Neurosurgery.
• Alderson L, Harsh GR IV. Surgical Treatment of Spinal Lymphoma. In: Ropper A, ed. Current Opinion in Neurology, 1994.
• Cher L, Harsh GR IV. Surgical Treatment of Multiple Brain Metastases. In: Ropper A, ed. Current Opinion in Neurology, 1995.
• Rosenberg W, Harsh GR IV. Gunshot Wounds to the Head. In: Wilkins RH, Rengachary SS, ed. Neurosurgery, in press.
• Harsh GR IV, Wilson CB. Clinical-pathological correlations and results of trans-sphenoidal resection in 539 cases of endocrine-inactive pituitary adenoma. In preparation.
• Harsh GR IV, Wilson CB. Pituitary apoplexy in nonsecreting pituitary adenomas. In preparation.
• Harsh GR IV, Hoffman WJ. Calcified chronic subdural empyema: resection and repair by free latissimus dorsi muscle graft. In preparation.
• Harsh GR, Butler W. Principles of stereotactic radiosurgery of the brain. Western Journal of Medicine. In preparation.
• Pardo FS, Aronen HJ, Kennedy D, Moulton G, Paiva K, Okunieff P, Schmidt EV, Hochberg FH, Harsh GR, Fischman AJ, Linggood RMA, Rosen B. Functional cerebral imaging in the evaluation and radiotherapeutic treatment planning of patients with malignant gliomas. Int J Radiation Oncology Biol Phys 30:663-669, 1994.
• Harsh GR. Molecular genetic screening for children at risk of neurofibromatosis. Archives of Otolaryngology - Head and Neck Surgery.
• Alderson LM, Castleberg RL, Harsh GR IV, Louis DN, Henson J. Human gliomas with wild-type p53 express bcl-2. Cancer Research 1995; 55:999-1001.
• Raffel C, Ueki K, Harsh GR IV, Louis DN. The multiple tumor suppressor 1/cyclin dependent kinase inhibitor 2 gene (MTS1/CDKN2) in human central nervous system primitive neuroectodermal tumor. Neurosurgery. In press.
• Sinha B, Harsh GR, Reeves SR. Tyrosine phosphoryolation within the N-terminal SH2 domain of SH-PTP2 increases binding affinity for the EGF receptor. Submitted, 1995.
• Reeves SA, Sinha B, Baur I, Reinhold D, Harsh GR. The SH-PTP2 phosphatase can inhibit EGF-dependent cell growth in a negative manner. Submitted, 1995.
• Paulus W, Baur I, Breakefield XO, Harsh GR IV, Reeves SA. Regulated expression of the diphtheria toxin A gene in human tumor cells using prokaryotic transcription control elements. Submitted, 1995.
• Tatter SB , Wilson CB, Harsh GR IV. Neuroepithelial tumors of the adult brain. In Youmans JR, ed. Neurological Surgery, Fourth Edition. W.B. Saunders Co., Philadelphia, in press, 1995.
• Raffel C, Harsh G, eds. The Molecular Biology of Neurosurgical Disease. Williams and Wilkins. In preparation. 1995.
• Harsh G, ed. Cerebral Metastasis. W. B. Saunders. In preparation. 1995.