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Chiocca Publications Chiocca Pubs 2001 Chiocca Pubs 2000 Chiocca Pubs 1999

Selected Publications:

Chiocca E.A., Choi B.B., Cai W., DeLuca N.A., Schaffer P.A., DiFiglia M., Breakefield X.O., Martuza R.L.: Transfer and expression of the lac Z gene in rat brain neurons mediated by herpes simplex virus mutants. New Biol. 2: 739-746, 1990.

Yu J., Wei M.X., Chiocca E.A., Martuza R.L., Tepper R.L.: Treatment of human glioma by engineered interleukin-4 secreting cells. Cancer Res 53, 3125-3128, 1993.

Chiocca E.A., Tamiya T., Boviatsis, E.J., Filipek, P.A., Breakefield X.O., Kennedy D.N.: Gene therapy for gliomas using virus vectors. Neuroimmunol. Res. 6 (Japan), 23-32, 1993.

Boviatsis E.J., Chase M., Wei M.X., Tamiya T., Hurford R.K. Jr., Kowall N.W., Tepper R.I., Breakefield X.O., Chiocca E.A.: Gene transfer into experimental brain tumors mediated by adenovirus, herpes simplex virus (HSV), and retrovirus vectors. Human Gene Therapy 5, 183-191, 1994.

Pakzaban P. and Chiocca E.A : Nerve growth factor protects against herpes simplex virus type 1 neurotoxicity in the rat striatum. NeuroReport 5, 993-996, 1994.

Scharf J.M., Boviatsis E.J., Fleet C., Breakefield X.O., and Chiocca E.A.: Genetically modified rat 9L gliosarcoma cells facilitate detection of infiltrating tumor cells in a rat model of brain neoplasms. Transgenics 1, 219-224, 1994.

M.X. Wei, T. Tamiya, M. Chase, E.J. Boviatsis, T.K.H. Chang, F. H. Hochberg, N.W. Kowall, D.J. Waxman, X.O. Breakefield, E.A. Chiocca. Experimental tumor therapy in mice with the cyclophosphamide-activating cytochrome P450 2B1 gene. Human Gene Therapy 5, 969-978, 1994.

Boviatsis E.J., Scharf J.M., Chase M., Harrington K., Breakefield X.O., Chiocca E.A.: Antitumor activity and reporter gene transfer into rat brain neoplasms inculated with herpes simplex virus vectors defective in thymidine kinase or ribonucleotide reductase. Gene Therapy 1, 323-331, 1994.

E. A. Chiocca, E. J. Boviatsis, R. M. Westmark, M. P. Short, E. P. Richardson, N.T. Zervas. Deep sylvian fissure meningioma without dural attachment in an adult. Case report. Neurosurgery , 944-946, 1994.

Boviatsis, E.J., Park, J.S., Sena-Esteves, M., Kramm, C., Chase, M., Efird, J., Wei, M.X., Breakefield, X.O., Chiocca, E.A.: Long- term survival of rats harboring brain tumors treated with ganciclovir and a herpes simplex virus vector that maintains an intact thymidine kinase gene. Cancer Research 54, 5745-5751, 1994.

Tamiya, T., Wei, M.X., Breakefield, X.O., Chiocca, E.A., Ohmoto, T.: Gene therapy for brain tumors: gene therapy for brain tumors using prodrug-sensitivity genes. Neurological Surgery (Japan) 22, 1099-1110, 1994.

Wei, M.X., Tamiya, T., Hurford, R.K., Boviatsis, E.J., Tepper, R.I., Chiocca, E.A.: Enhancement of interleukin 4-mediated tumor regression in athymic mice by in situ retroviral gene transfer. Human Gene Therapy 6, 439-445, 1995.

Tamiya, T., Wei. M.X., Ono, Y., Chase, M., Breakefield, X.O., Chiocca, E.A.: Transgene inheritance and retroviral infection contribute to the efficiency of gene expression in solid tumors inoculated with retroviral vector producer cells. Gene Therapy 2, 531-538, 1995.

Wei M.X., Tamiya, T., Rhee, R.J., Breakefield X.O., and Chiocca, E.A.: Diffusible cytotoxic metabolites contribute to the in vitro bystander effect associated with cyclophosphamide/ cytochrome P450 2B1 gene therapy. Clinical Cancer Research 1, 1171-1177, 1995.

Speliotes E.K., Wei M.X., Weise J., Fleet C., Do T., Shanti B., Chiocca E.A., Finklestein S.P., and Breakefield X.O.: Signal Peptide-basic fibroblast growth factor (sp-bFGF) transforms fibroblast line in vitro but restricts fibroma growth in brain. Transgenics 1, 573-584 , 1995.

Rainov, N.G., Zimmer, C., Chase, M., Kramm, C., Chiocca, E.A., Weissleder, R., Breakefield, X.O.: Selective intra-arterial delivery of viral and microcrystalline particles to experimental brain tumors. Human Gene Therapy 6: 1543-1552, 1995.

Muldoon, L.L., Nilaver, G., Kroll, R.A., Pagel, M.A., Breakefield, X.O., Chiocca, E.A., Davidson, B.L., Weissleder, R., Neuwelt, E.A.: Use of monocrystalline iron oxide nanocompound to monitor the distribution of adenovirus and herpesvirus in normal rat brain: comparison of delivery by direct inoculation and osmotic blood-brain barrier disruption. Am. J. Pathol. 147: 1840- 1851, 1995.

Kramm, C.M., Sena-Esteves, M., Barnett, F.H., Rainov, N.G., Schuback, D.E., Yu, J.S., Pechan, P.A., Paulus, W., Chiocca, E.A., Breakefield, X.O.: Gene Therapy for Brain Tumors (Review). Brain Pathology 5: 345-381, 1995

Kramm, C.M., Rainov, N.G., Sena-Esteves, M., Chase, M., Pechan, P., Chiocca, E.A., Breakefield, X.O.: Herpes vector-mediated delivery of thymidine kinase gene to disseminated CNS tumors. Human Gene Therapy 7: 291-300, 1996.

Tamiya, T., Ono, Y., Wei, M.X. Mroz, P., Moolten, F.L., and Chiocca, E.A.: The Escherichia Coli gpt gene sensitizes rat glioma cells to killing by 6-thioxanthine or 6-thioguanine. Cancer Gene Therapy 3: 155-162, 1996.

Rainov, N.G., Kramm, C.K., Aboody-Gutterman, K., Chase, M.,Ueki, K., , Louis, D.N., Harsh IV, G.R., Chiocca, E.A., Breakefield, X.O.: Retrovirus-mediated gene therapy of experimental brain neoplasms using the HSV-TK/ganciclovir paradigm. Cancer Gene Therapy 3: 99-106, 1996.

Pechan, P., , Chase, M., DeLuca, N.A., Thompson, R., Chiocca, E.A. and Breakefield, X.O.: A novel herpes simplex virus "piggyback" packaging system for amplicon vectors. Human Gene therapy: in press, 1996.

Kramm, C.K., Rainov, N.G., Sena-Esteves, M., Barnett, F.H., Chase, M., Chiocca, E.A., Breakefield, X.O.: Long-term survival in a rodent model of disseminated brain tumors by combined intrathecal delivery of herpes vectors and ganciclovir treatment. Human Gene Therapy: in press, 1996

CHAPTERS

Chiocca E.A., Andersen J.K., Takamiya Y., Martuza R.L., Breakefield X.O. Virus-mediated Genetic Treatment of Rodent Gliomas. In: Gene Therapeutics. J.A. Wolff ed. (Birkhauser Press Publishing Co., Boston), 1994, pp. 245-262.

Chiocca, E.A.: Genetic treatment of brain tumors with the cyclophosphamide-activating CYP2B1 gene. Clinical Neurosurgery vol.42, 1995, pp. 370-382.

Wei, M.X., Tamiya, T., Breakefield, X.O., Chiocca, E.A.: Virus vector mediated transfer of drug-sensitivity genes for experimental brain tumor therapy. In: Viral vectors: gene therapy and neuroscience applications. (M.G. Kaplitt and A.D. Loewy, eds.) Academic Press, San Diego, CA, 1995, pp. 239-259.

Breakefield, X.O., Kramm, C.M., Chiocca E.A., Pechan, P.: Herpes simplex virus vectors for tumor therapy. In: The Internet book of Gene Therapy: Cancer Gene Therapeutics. (R. Sobol and K. Scanlon, eds.), 1995, pp 41-56.

Kramm, C., Breakefield, X.O., Chiocca E.A.: Genetic strategies against brain tumors. In: The Internet book of Gene Therapy: Cancer Gene Therapeutics. (R. Sobol and K. Scanlon, eds.), 1995, pp 235-246.

Chiocca, E.A. and Harsh, G.R. IV: Gene transfer technology and its application to brain tumor therapy. In: The molecular basis for neurological surgery. (C. Raffel and G.R. Harsh, eds.), 1996, in press.