The Proton Beam Unit was founded in 1962 and
has the largest experience
with stereotactic radiosurgery of any center
in the United States. Information regarding non-invasive
proton beam radiosurgery and fractionated radiosurgery
for brain and spinal tumors and arteriovenous
The Purpose of this Center is to provide a complete
range of services for the diagnosis, and treatment
with non-invasive proton beam radiosurgery and
fractionated radiosurgery for brain and spinal
tumors and arteriovenous malformations. Patients
may be referred for consultation only, care in
partnership with referring physician, or complete
Bragg Peak Proton Beam Radiosurgery
Unit - The Proton Beam Unit was founded in 1962
and has the largest experience with stereotactic
radiosurgery of any center in the United States.
Proton beam offers certain theoretical advantages
over other modalities of stereotactic radiosurgery
(i.e. gamma knife and linear accelerators) because
it makes use of the quantum wave properties of protons
to reduces doses to surrounding tissue beyond the
target to a theoretical minimum of zero. In practice,
the proton facility offers advantages for the treatment
of unusually shaped brain tumors and arteriovenous
malformations. The homogeneous doses delivered also
makes fractionated therapy possible. Proton beam
radiosurgery also has the ability to treat tumors
outside of the cranial cavity. These properties
make it the ideal post-resection therapy for many
chordomas and certain chondrosarcomas of the spine
and skull base as well as an excellent mode of therapy
for many other types of tumors.
HCL: The Harvard
Cyclotron Laboratory (HCL) has now closed.
Newsletters' have been transfered to the MGH
PTCOG web and the main PSI-PTCOG
NPTC: Information, proton radiosurgery
treatments and support services have been transfered
to the new The Northeast
Proton Therapy Center (NPTC). Located on the
main hospital campus of the Massachusetts
General Hospital (MGH), the NPTC represents
the forefront of technological advancement in
radiation therapy. The construction of the facility
was jointly funded by the hospital and the National
Cancer Institute to meet the increasing medical
demand for high precision radiation therapy provided
by proton therapy. The program builds on more
than forty years of pioneering work and experience
gained by the physicians, physicists, and clinical
support personnel at Harvard University's Cyclotron
Laboratory where more than nine thousand patients
were treated with proton therapy from 1961 to
it's closing in 2002.
- Rabinov JD, Brisman JL, Cole AJ, Lee PL, Bussiere
MR, Chapman PH, Loeffler JS, Cosgrove GR, Chaves
T, Gonzalez RG.: MRI changes in the rat hippocampus
following proton radiosurgery. Stereotact Funct
- Brisman JL, Cole AJ, Cosgrove GR, Thornton
AF, Rabinov J, Bussiere M, Bradley-Moore M,
Hedley-Whyte T, Chapman PH.: Radiosurgery of
the rat hippocampus: magnetic resonance imaging,
neurophysiological, histological, and behavioral
studies. Neurosurgery. 2003 Oct;53(4):951-61;
- Weber DC, Chan AW, Bussiere MR, Harsh GR 4th,
Ancukiewicz M, Barker FG 2nd, Thornton AT, Martuza
RL, Nadol JB Jr, Chapman PH, Loeffler JS.: Proton
beam radiosurgery for vestibular schwannoma:
tumor control and cranial nerve toxicity. Neurosurgery.
2003 Sep;53(3):577-86; discussion 586-8.
- Barker FG 2nd, Butler WE, Lyons S, Cascio
E, Ogilvy CS, Loeffler JS, Chapman PH.: Dose-volume
prediction of radiation-related complications
after proton beam radiosurgery for cerebral
arteriovenous malformations. J Neurosurg. 2003
- Harsh GR, Thornton AF, Chapman PH, Bussiere
MR, Rabinov JD, Loeffler JS.: Proton beam stereotactic
radiosurgery of vestibular schwannomas. Int
J Radiat Oncol Biol Phys. 2002 Sep 1;54(1):35-44.
- Barker FG 2nd, Amin-Hanjani S, Butler WE,
Lyons S, Ojemann RG, Chapman PH, Ogilvy CS.:
Temporal clustering of hemorrhages from untreated
cavernous malformations of the central nervous
system. Neurosurgery. 2001 Jul;49(1):15-24;
- Chapman PH, Tarbell: Proton beam therapy.
In: Pediatric Neurosurgery. Surgery of the Developing
Nervous System, 4th ed. Ed: McLone DG: WB Saunders:
Philadelphia, pp. 1255-1262, 2001.
- Loeffler JS, Singer RJ, Chapman PH, Ogilvy
CS: Proton-beam radiation therapy. In: LINAC
and Gamma Knife Radiosurgery. Ed: Germano IM.
The American Association of Neurological Surgeons:
Park Ridge, IL, pp. 71-74, 2000.
- Harsh G, Loeffler JS, Thornton A, Smith A,
Bussiere M, Chapman PH: Stereotactic Proton
Radiosurgery. Neurosurg Clin N Am 1999; 10:243-256.
- Tatter SB, Butler WE, Chapman PH. Technical
and clinical aspects of proton-beam stereotactic
radiosurgery. In: Textbook of Stereotactic and
functional Neurosurgery. Eds: Gildenberg PL,
Tasker RR. McGraw-Hill, New York pp. 705-710,
- Serago CF, Thornton AF, Urie MM, Chapman
P, Verhey L, Rosenthal SJ, Gall KP, Niemierko
A: Comparison of proton and x-ray conformal
dose distributions for radiosurgery applications.
Med Phys 22:2111-16, 1995.
- Butler WE, Ogilvy CS, Chapman PH, Verhy L
, Zervas NT. "Stereotactic alignment for
Bragg peak radiosurgery." In Radiosurgery:
Baseline and Trends, ed. L. Steiner. 85-91.
New York: Raven Press, 1992.
- Chapman PH, Ogilvy CS , Butler WE. "A
new stereotactic alignment system for charged-particle
radiosurgery at the Harvard Cyclotron Laboratory,
Boston." In Stereotactic Radiosurgery,
ed. Eben Alexander III, Jay S. Loeffler, and
L. Dade Lunsford. 105-108. New York: McGraw-Hill,
- De Salles AA, Asfora WT, Abe M, Kjellberg
RN: Transposition of target information from
the magnetic resonance and computed tomography
scan images to conventional X-ray stereotactic
space. Applied Neurophysiology 50: 23-32, 1987.
- Gall KP, Verhey LJ, Wagner M: Computer-assisted
positioning of radiotherapy patients using implanted
radiopaque fiducials. Medical Physics 20: 1153-9,
- Kjellberg RN, Hanamura T, Davis KR, Lyons
SL , Adams RD: Bragg-peak proton-beam therapy
for arteriovenous malformations of the brain.
New England Journal of Medicine 309: 269-74,
- Kjellberg RN, Shintani A, Frantz AG, Kliman
B: Proton-beam therapy in acromegaly. New England
Journal of Medicine 278: 689-95, 1968.
- Urie MM, Fullerton B, Tatsuzaki H, Birnbaum
S, Suit HD, Convery K, Skates , Goitein M: A
dose response analysis of injury to cranial
nerves and/or nuclei following proton beam radiation
therapy. International Journal of Radiation
Oncology, Biology, Physics 23: 27-39, 1992.
Information on the
Cyclotron Proton Beam,
Neurosurgical Radiosurgery Unit
H. Chapman, M.D.
Languages: English, Arabic, German
For referrals or more information
| Louise B. Hanscom
Proton Radiosurgery Group
Massachusetts General Hospital
Boston, Massachusetts 02114
Note: For information
about proton beam treatment for prostate
Note: For information
about proton beam treatment for skull
base chordomas contact:
Note: For information
about proton beam treatment for spine
|Thomas F. DeLaney,
Neurosurgery @ MGH